Show simple item record

dc.contributor.authorBradshaw, CS
dc.contributor.authorMorton, AN
dc.contributor.authorHocking, J
dc.contributor.authorGarland, SM
dc.contributor.authorMorris, MB
dc.contributor.authorMoss, LM
dc.contributor.authorHorvath, LB
dc.contributor.authorKuzevska, I
dc.contributor.authorFairley, CK
dc.date.available2014-05-21T19:30:52Z
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.available2005-12-28
dc.date.issued2006-06-01
dc.identifierpii: JID36020
dc.identifier.citationBradshaw, C. S., Morton, A. N., Hocking, J., Garland, S. M., Morris, M. B., Moss, L. M., Horvath, L. B., Kuzevska, I. & Fairley, C. K. (2006). High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. JOURNAL OF INFECTIOUS DISEASES, 193 (11), pp.1478-1486. https://doi.org/10.1086/503780.
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/11343/26393
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractBACKGROUND: We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence. METHODS: Women with symptomatic BV (a Nugent score [NS] of 7-10 or of 4-6 with >or=3 Amsel criteria) were enrolled. BV was treated with 400 mg of oral metronidazole twice a day for 7 days. Participants completed a questionnaire and vaginal swabs were collected at 1, 3, 6, and 12 months; the study end point was an NS of 7-10. RESULTS: A total of 121 (87%) women with an NS of 7-10 and 18 (13%) with an NS of 4-6 and >or=3 Amsel criteria were enrolled; 130 (94%) returned >or=1 vaginal samples. Sixty-eight women (58% [95% confidence interval {CI}, 49%-66%]) had a recurrence of BV (NS 7-10), and 84 (69% [95% CI, 61%-77%]) had a recurrence of abnormal vaginal flora (NS 4-10) by 12 months. A past history of BV, a regular sex partner throughout the study, and female sex partners were significantly associated with recurrence of BV and abnormal vaginal flora by multivariate analysis; the use of hormonal contraception had a negative association with recurrence. CONCLUSION: Current recommended treatment is not preventing the recurrence of BV or abnormal vaginal flora in the majority of women; factors associated with recurrence support a possible role for sexual transmission in the pathogenesis of recurrent BV.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.subjectPreventive Medicine; Women's Health; Preventive Medicine
dc.titleHigh recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
dc.typeJournal Article
dc.identifier.doi10.1086/503780
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPopulation Health
melbourne.source.titleJOURNAL OF INFECTIOUS DISEASES
melbourne.source.volume193
melbourne.source.issue11
melbourne.source.pages1478-1486
dc.research.coderfcd321206
dc.research.codeseo1998730201
dc.research.codeseo1998730213
melbourne.publicationid54831
melbourne.elementsid279081
melbourne.contributor.authorBRADSHAW, CATRIONA SUSAN
melbourne.contributor.authorHocking, Jane
melbourne.contributor.authorWark, Suzanne
melbourne.contributor.authorHORVATH, LEONIE
melbourne.contributor.authorKuzevska, Irene
melbourne.contributor.authorFairley, Christopher
dc.identifier.eissn1537-6613
pubs.acceptance.date2005-12-28
melbourne.accessrightsThis item is currently not available from this repository


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record