A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1
Author
Kelleher, AD; Puls, RL; Bebbington, M; Boyle, D; Ffrench, R; Kent, SJ; Kippax, S; Purcell, DFJ; Thomson, S; Wand, H; ...Date
2006-01-09Source Title
AIDSPublisher
LIPPINCOTT WILLIAMS & WILKINSAffiliation
Microbiology And ImmunologyMetadata
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Journal ArticleCitations
Kelleher, A. D., Puls, R. L., Bebbington, M., Boyle, D., Ffrench, R., Kent, S. J., Kippax, S., Purcell, D. F. J., Thomson, S., Wand, H., Cooper, D. A. & Emery, S. (2006). A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1. AIDS, 20 (2), pp.294-297. https://doi.org/10.1097/01.aids.0000199819.40079.e9.Access Status
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C1 - Journal Articles Refereed
Abstract
An HIV-vaccine consisting of a DNA prime, recombinant fowlpox virus (rFPV) boost was evaluated in a double-blind placebo controlled trial. One milligram of pHIS-HIV-B expressing mutated gag, pol, env, vpu, tat and rev was administered at weeks 0 and 4 boosted by 5 x 10(7) pfu rFPV-HIV-B expressing gag/pol at week 8. The vaccine regimen was safe, but there was no difference between vaccine (n = 18) and placebo recipients (n = 6) for Gag or Pol-specific T-cell immune responses at week 9.
Keywords
Medical Virology ; Infectious DiseasesExport Reference in RIS Format
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