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    Development of Vaccines against Visceral Leishmaniasis.

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    48
    Author
    Evans, KJ; Kedzierski, L
    Date
    2012
    Source Title
    Journal of Tropical Medicine
    Publisher
    Hindawi Limited
    University of Melbourne Author/s
    EVANS, KRYSTAL; Kedzierski, Lukasz
    Affiliation
    Medical Biology (W.E.H.I.)
    Veterinary and Agricultural Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Evans, K. J. & Kedzierski, L. (2012). Development of Vaccines against Visceral Leishmaniasis.. J Trop Med, 2012 (2012), pp.892817-. https://doi.org/10.1155/2012/892817.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/264362
    DOI
    10.1155/2012/892817
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170777
    Abstract
    Leishmaniasis is a neglected disease resulting in a global morbidity of 2,090 thousand Disability-Adjusted Life Years and a mortality rate of approximately 60,000 per year. Among the three clinical forms of leishmaniasis (cutaneous, mucosal, and visceral), visceral leishmaniasis (VL) accounts for the majority of mortality, as if left untreated VL is almost always fatal. Caused by infection with Leishmania donovani or L. infantum, VL represents a serious public health problem in endemic regions and is rapidly emerging as an opportunistic infection in HIV patients. To date, no vaccine exists for VL or any other form of leishmaniasis. In endemic areas, the majority of those infected do not develop clinical symptoms and past infection leads to robust immunity against reinfection. Thus the development of vaccine for Leishmania is a realistic public health goal, and this paper summarizes advances in vaccination strategies against VL.

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