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dc.contributor.authorCunningham, CP
dc.contributor.authorKimpton, WG
dc.contributor.authorHolder, JE
dc.contributor.authorCahill, RNP
dc.date.available2014-05-21T19:33:08Z
dc.date.issued2001-03-01
dc.identifierpii: 10.1002/1521-4141(200103)31:3<802::AID-IMMU802>3.0.CO;2-P
dc.identifier.citationCunningham, C. P., Kimpton, W. G., Holder, J. E. & Cahill, R. N. P. (2001). Thymic export in aged sheep: a continuous role for the thymus throughout pre- and postnatal life. EUROPEAN JOURNAL OF IMMUNOLOGY, 31 (3), pp.802-811. https://doi.org/10.1002/1521-4141(200103)31:3<802::AID-IMMU802>3.3.CO;2-G.
dc.identifier.issn0014-2980
dc.identifier.urihttp://hdl.handle.net/11343/26449
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractA diverse repertoire among peripheral T cells is established in early life by thymic export when the naive T cell pool is first formed. In contrast, during adult life the thymus has been thought to play only a minor role in T cell homeostasis. As individuals age there is an increasing proportion of peripheral T cells bearing a memory phenotype, as well as a corresponding decrease in the number of naive T cells. The change in the composition of the peripheral T cell pool with age is thought to occur as a result of reduced or completely curtailed thymic export following thymic involution at puberty together with the antigen-driven expansion of naive T cells in the periphery. We examined thymic export throughout life in fetal, neonatal and aged sheep. We found that the thymus in adult animals showed an efficiency of production and export on a per gram basis equivalent to that observed for much younger animals, and continued to export substantial numbers of T cells long after puberty. The data demonstrate that naive T cells constantly enter the peripheral T cell pool at the same rate throughout fetal, neonatal and adult life, and that one in every 50 T cells in the peripheral lymphoid tissues of aged sheep had emigrated from the thymus in the previous 24 h. The data suggest that restoration by the thymus of a normal peripheral T cell repertoire in chronic T cell-depleting conditions should be possible in adult patients, provided the thymus is not damaged by disease or therapy.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherWILEY
dc.subjectImmunology ; Biological Sciences
dc.titleThymic export in aged sheep: a continuous role for the thymus throughout pre- and postnatal life
dc.typeJournal Article
dc.identifier.doi10.1002/1521-4141(200103)31:3<802::AID-IMMU802>3.3.CO;2-G
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentVeterinary Science
melbourne.source.titleEuropean Journal of Immunology
melbourne.source.volume31
melbourne.source.issue3
melbourne.source.pages802-811
melbourne.publicationid1204
melbourne.elementsid247327
melbourne.contributor.authorKimpton, Wayne
melbourne.contributor.authorCAHILL, ROSS
melbourne.contributor.authorCUNNINGHAM, CRAIG PATRICK
melbourne.contributor.authorHOLDER, JOANNE ELIZABETH
dc.identifier.eissn1521-4141
melbourne.accessrightsThis item is currently not available from this repository


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