Epilepsy, depression and antidepressant drugs
AuthorSalzberg, MR; Vajda, FJE
Source TitleJOURNAL OF CLINICAL NEUROSCIENCE
PublisherELSEVIER SCI LTD
AffiliationMedicine - St Vincent'S Hospital
Document TypeJournal Article
CitationsSalzberg, M. R. & Vajda, F. J. E. (2001). Epilepsy, depression and antidepressant drugs. JOURNAL OF CLINICAL NEUROSCIENCE, 8 (3), pp.209-215. https://doi.org/10.1054/jocn.2000.0896.
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C1 - Journal Articles Refereed
Apart from constituting an important management problem, depression coexisting with epilepsy is also an interesting psychiatric phenomenon, with multiple interacting biological, psychological and social factors involved in its causation. New research approaches to the study of epilepsy and depression, including neuroimaging, neurochemical and neuroendocrine techniques, and the arrival of new classes of antidepressants in recent years, suggest it is timely to reconsider this topic. We review current knowledge of the prevalence and causes of interictal depression in epilepsy, focussing mainly on neurobiological factors, and give an overview of recent concepts concerning the management of depression. We also discuss pharmacological treatment of depression in epilepsy, focussing on the association between antidepressants and seizures, and drug interactions.
KeywordsClinical Sciences not elsewhere classified; Mental Health
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