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    The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

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    Author
    Borg, NA; Ely, LK; Beddoe, T; Macdonald, WA; Reid, HH; Clements, CS; Purcell, AW; Kjer-Nielsen, L; Miles, JJ; Burrows, SR; ...
    Date
    2005-02-01
    Source Title
    NATURE IMMUNOLOGY
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    PURCELL, ANTHONY; Kjer-Nielsen, Lars; McCluskey, James
    Affiliation
    Microbiology And Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Borg, N. A., Ely, L. K., Beddoe, T., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J. (2005). The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. NATURE IMMUNOLOGY, 6 (2), pp.171-180. https://doi.org/10.1038/ni1155.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26466
    DOI
    10.1038/ni1155
    Description

    C1 - Journal Articles Refereed

    Abstract
    The energetic bases of T cell recognition are unclear. Here, we studied the 'energetic landscape' of peptide-major histocompatibility complex (pMHC) recognition by an immunodominant alphabeta T cell receptor (TCR). We quantified and evaluated the effect of natural and systematic substitutions in the complementarity-determining region (CDR) loops on ligand binding in the context of the structural detail of each component of the immunodominant TCR-pMHC complex. The CDR1 and CDR2 loops contributed minimal energy through direct recognition of the antigen and instead had a chief function in stabilizing the ligated CDR3 loops. The underlying energetic basis for recognition lay in the CDR3 loops. Therefore the energetic burden of the CDR loops in the TCR-pMHC interaction is variable among TCRs, reflecting the inherent adaptability of the TCR in ligating different ligands.
    Keywords
    Cellular Immunology; Immune System and Allergy

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