Show simple item record

dc.contributor.authorTynan, FE
dc.contributor.authorBurrows, SR
dc.contributor.authorBuckle, AM
dc.contributor.authorClements, CS
dc.contributor.authorBorg, NA
dc.contributor.authorMiles, JJ
dc.contributor.authorBeddoe, T
dc.contributor.authorWhisstock, JC
dc.contributor.authorWilce, MC
dc.contributor.authorSilins, SL
dc.contributor.authorBurrows, JM
dc.contributor.authorKjer-Nielsen, L
dc.contributor.authorKostenko, L
dc.contributor.authorPurcell, AW
dc.contributor.authorMcCluskey, J
dc.contributor.authorRossjohn, J
dc.identifierpii: ni1257
dc.identifier.citationTynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T., Whisstock, J. C., Wilce, M. C., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J. (2005). T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. NATURE IMMUNOLOGY, 6 (11), pp.1114-1122.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractUnusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still preserving MHC restriction, we have determined here the structure of a TCR in complex with HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was atypical of TCR-peptide-MHC class I interactions, being dominated at the interface by peptide-mediated interactions. The TCR assumed two distinct orientations, swiveling on top of the centrally bulged, rigid peptide such that only limited contacts were made with MHC class I. Although the TCR-peptide recognition resembled an antibody-antigen interaction, the TCR-MHC class I contacts defined a minimal 'generic footprint' of MHC-restriction. Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction.
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleT cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleNature Immunology
melbourne.contributor.authorKjer-Nielsen, Lars
melbourne.contributor.authorKostenko, Lyudmila
melbourne.contributor.authorPURCELL, ANTHONY
melbourne.contributor.authorMcCluskey, James
melbourne.accessrightsThis item is currently not available from this repository

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record