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    Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation

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    Author
    Wong, M; Toh, L; Wilson, A; Rowley, K; Karschimkus, C; Prior, D; Romas, E; Clemens, L; Dragicevic, G; Harianto, H; ...
    Date
    2003-01-01
    Source Title
    ARTHRITIS AND RHEUMATISM
    Publisher
    WILEY
    University of Melbourne Author/s
    Wilson, Andrew; ROWLEY, KEVIN; KARSCHIMKUS, CONNIE; Prior, David; Romas, Evangelos; DRAGICEVIC, GEORGE; Wicks, Ian; McColl, Geoffrey; Best, James; Jenkins, Alicia
    Affiliation
    Medicine - St Vincent'S Hospital
    Metadata
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    Document Type
    Journal Article
    Citations
    Wong, M., Toh, L., Wilson, A., Rowley, K., Karschimkus, C., Prior, D., Romas, E., Clemens, L., Dragicevic, G., Harianto, H., Wicks, I., McColl, G., Best, J. & Jenkins, A. (2003). Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation. ARTHRITIS AND RHEUMATISM, 48 (1), pp.81-89. https://doi.org/10.1002/art.10748.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26493
    DOI
    10.1002/art.10748
    Description

    C1 - Journal Articles Refereed

    Abstract
    OBJECTIVE: Rheumatoid arthritis (RA) is associated with increased rates of cardiovascular disease. Reduced small artery elasticity (SAE) and large artery elasticity (LAE) and increased systemic vascular resistance (SVR) have been found in other high-risk groups. In the present study, we sought to determine whether arterial elasticity was reduced and SVR was increased in RA patients compared with controls matched for coronary artery disease (CAD) status, and to relate the results to vascular disease risk factors, including measures of inflammation. METHODS: Arterial elasticity was assessed by pulse wave analysis in RA patients with (n = 15) and without (n = 38) CAD, and in controls matched 1:1 for age, sex, and CAD status. Vascular risk factors, including high-sensitivity C-reactive protein (hsCRP), soluble vascular cell adhesion molecule 1 (sVCAM-1), and serum amyloid A (SAA) levels, were assessed. RESULTS: SAE and LAE were significantly lower and SVR was significantly higher in RA patients than in controls. RA patients also had higher levels of hsCRP, SAA, and sVCAM-1. SAE and LAE values were inversely correlated with markers of inflammation. Associations of SAE and LAE with RA were independent of conventional risk factors, but were dependent on markers of inflammation. CONCLUSION: Vascular function is abnormal in RA, with reduced SAE and LAE and increased SVR relative to controls. Arterial elasticity is inversely associated with measures of inflammation. These measures may be clinically useful in the detection and monitoring of vascular disease in RA.
    Keywords
    Rheumatology and Arthritis ; Skeletal System and Disorders (incl. Arthritis)

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