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    Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

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    Author
    Foth, BJ; Ralph, SA; Tonkin, CJ; Struck, NS; Fraunholz, M; Roos, DS; Cowman, AF; McFadden, GI
    Date
    2003-01-31
    Source Title
    SCIENCE
    Publisher
    AMER ASSOC ADVANCEMENT SCIENCE
    University of Melbourne Author/s
    RALPH, STUART A; TONKIN, CHRISTOPHER JOHN; McFadden, Geoffrey; Ralph, Stuart; Cowman, Alan; FOTH, BERNARDO JAVIER; STRUCK, NICOLE
    Affiliation
    Botany
    Metadata
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    Document Type
    Journal Article
    Citations
    Foth, B. J., Ralph, S. A., Tonkin, C. J., Struck, N. S., Fraunholz, M., Roos, D. S., Cowman, A. F. & McFadden, G. I. (2003). Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. SCIENCE, 299 (5607), pp.705-708. https://doi.org/10.1126/science.1078599.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26497
    DOI
    10.1126/science.1078599
    Description

    C1 - Journal Articles Refereed

    Abstract
    Transit peptides mediate protein targeting into plastids and are only poorly understood. We extracted amino acid features from transit peptides that target proteins to the relict plastid (apicoplast) of malaria parasites. Based on these amino acid characteristics, we identified 466 putative apicoplast proteins in the Plasmodium falciparum genome. Altering the specific charge characteristics in a model transit peptide by site-directed mutagenesis severely disrupted organellar targeting in vivo. Similarly, putative Hsp70 (DnaK) binding sites present in the transit peptide proved to be important for correct targeting.
    Keywords
    Botany not elsewhere classified; Biological Sciences

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