The cross-priming APC requires a Rel-dependent signal to induce CTL
AuthorMintern, JD; Belz, G; Gerondakis, S; Carbone, FR; Heath, WR
Source TitleJOURNAL OF IMMUNOLOGY
PublisherAMER ASSOC IMMUNOLOGISTS
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsMintern, JD; Belz, G; Gerondakis, S; Carbone, FR; Heath, WR, The cross-priming APC requires a Rel-dependent signal to induce CTL, JOURNAL OF IMMUNOLOGY, 2002, 168 (7), pp. 3283 - 3287
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C1 - Journal Articles Refereed
Induction of OVA-specific CTL by cross-priming requires help from CD4 T cells, which use CD154 to signal CD40 on the APC. To further dissect the molecular pathways involved in cross-priming, we examined the role of Rel, an NF-kappaB family member. c-rel(-/-) mice failed to generate OVA-specific CTL by cross-priming, but could induce CTL to HSV-1. Using chimeric mice, Rel expression was shown to be required by the APC, but not by the T cells. Notably, the deficiency in Rel could be overcome by triggering CD40, implying that the APC required Rel before receipt of the CD40 signal. These data suggest that the cross-priming APC must receive two signals before it can stimulate CTL. The first signal is Rel dependent and is required before activation of CD4 helper T cells, which then deliver the second signal using CD154 to trigger CD40.
KeywordsCellular Immunology; Immune System and Allergy
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