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    The cross-priming APC requires a Rel-dependent signal to induce CTL

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    Author
    Mintern, JD; Belz, G; Gerondakis, S; Carbone, FR; Heath, WR
    Date
    2002-04-01
    Source Title
    JOURNAL OF IMMUNOLOGY
    Publisher
    AMER ASSOC IMMUNOLOGISTS
    University of Melbourne Author/s
    Mintern, Justine; Carbone, Francis; Heath, William
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Mintern, J. D., Belz, G., Gerondakis, S., Carbone, F. R. & Heath, W. R. (2002). The cross-priming APC requires a Rel-dependent signal to induce CTL. JOURNAL OF IMMUNOLOGY, 168 (7), pp.3283-3287. https://doi.org/10.4049/jimmunol.168.7.3283.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26506
    DOI
    10.4049/jimmunol.168.7.3283
    Description

    C1 - Journal Articles Refereed

    Abstract
    Induction of OVA-specific CTL by cross-priming requires help from CD4 T cells, which use CD154 to signal CD40 on the APC. To further dissect the molecular pathways involved in cross-priming, we examined the role of Rel, an NF-kappaB family member. c-rel(-/-) mice failed to generate OVA-specific CTL by cross-priming, but could induce CTL to HSV-1. Using chimeric mice, Rel expression was shown to be required by the APC, but not by the T cells. Notably, the deficiency in Rel could be overcome by triggering CD40, implying that the APC required Rel before receipt of the CD40 signal. These data suggest that the cross-priming APC must receive two signals before it can stimulate CTL. The first signal is Rel dependent and is required before activation of CD4 helper T cells, which then deliver the second signal using CD154 to trigger CD40.
    Keywords
    Cellular Immunology; Immune System and Allergy

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