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dc.contributor.authorMintern, JD
dc.contributor.authorBelz, G
dc.contributor.authorGerondakis, S
dc.contributor.authorCarbone, FR
dc.contributor.authorHeath, WR
dc.date.available2014-05-21T19:35:37Z
dc.date.issued2002-04-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174566400023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationMintern, J. D., Belz, G., Gerondakis, S., Carbone, F. R. & Heath, W. R. (2002). The cross-priming APC requires a Rel-dependent signal to induce CTL. JOURNAL OF IMMUNOLOGY, 168 (7), pp.3283-3287. https://doi.org/10.4049/jimmunol.168.7.3283.
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/11343/26506
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractInduction of OVA-specific CTL by cross-priming requires help from CD4 T cells, which use CD154 to signal CD40 on the APC. To further dissect the molecular pathways involved in cross-priming, we examined the role of Rel, an NF-kappaB family member. c-rel(-/-) mice failed to generate OVA-specific CTL by cross-priming, but could induce CTL to HSV-1. Using chimeric mice, Rel expression was shown to be required by the APC, but not by the T cells. Notably, the deficiency in Rel could be overcome by triggering CD40, implying that the APC required Rel before receipt of the CD40 signal. These data suggest that the cross-priming APC must receive two signals before it can stimulate CTL. The first signal is Rel dependent and is required before activation of CD4 helper T cells, which then deliver the second signal using CD154 to trigger CD40.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleThe cross-priming APC requires a Rel-dependent signal to induce CTL
dc.typeJournal Article
dc.identifier.doi10.4049/jimmunol.168.7.3283
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF IMMUNOLOGY
melbourne.source.volume168
melbourne.source.issue7
melbourne.source.pages3283-3287
dc.research.coderfcd320202
dc.research.codeseo1998730102
melbourne.publicationid76085
melbourne.elementsid287438
melbourne.contributor.authorMintern, Justine
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorHeath, William
dc.identifier.eissn1550-6606
melbourne.accessrightsThis item is currently not available from this repository


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