Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells
AuthorMintern, JD; Davey, GM; Belz, GT; Carbone, FR; Heath, WR
Source TitleJOURNAL OF IMMUNOLOGY
PublisherAMER ASSOC IMMUNOLOGISTS
University of Melbourne Author/sMintern, Justine; Carbone, Francis; Belz, Gabrielle; Heath, William; Davey, Gayle
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsMintern, J. D., Davey, G. M., Belz, G. T., Carbone, F. R. & Heath, W. R. (2002). Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells. JOURNAL OF IMMUNOLOGY, 168 (3), pp.977-980. https://doi.org/10.4049/jimmunol.168.3.977.
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C1 - Journal Articles Refereed
Generation of CTL immunity often depends on the availability of CD4 T cell help. In this report, we show that CTL responses induced by cross-priming can be converted from CD4-dependent to CD4-independent by increasing the frequency of CTL precursors. In the absence of CD4 T cells, high numbers of CTL precursors were able to expand in number and become effector CTL. The ability of high frequencies of CD8 T cells to override help was not due to their ability to signal CD40 via expression of CD154. These findings suggest that when precursor frequencies are high, priming of CD8 T cell responses may not require CD4 T cell help.
KeywordsCellular Immunology; Immune System and Allergy
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