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dc.contributor.authorMintern, JD
dc.contributor.authorDavey, GM
dc.contributor.authorBelz, GT
dc.contributor.authorCarbone, FR
dc.contributor.authorHeath, WR
dc.date.available2014-05-21T19:35:40Z
dc.date.issued2002-02-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000173429300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationMintern, J. D., Davey, G. M., Belz, G. T., Carbone, F. R. & Heath, W. R. (2002). Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells. JOURNAL OF IMMUNOLOGY, 168 (3), pp.977-980. https://doi.org/10.4049/jimmunol.168.3.977.
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/11343/26507
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractGeneration of CTL immunity often depends on the availability of CD4 T cell help. In this report, we show that CTL responses induced by cross-priming can be converted from CD4-dependent to CD4-independent by increasing the frequency of CTL precursors. In the absence of CD4 T cells, high numbers of CTL precursors were able to expand in number and become effector CTL. The ability of high frequencies of CD8 T cells to override help was not due to their ability to signal CD40 via expression of CD154. These findings suggest that when precursor frequencies are high, priming of CD8 T cell responses may not require CD4 T cell help.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleCutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells
dc.typeJournal Article
dc.identifier.doi10.4049/jimmunol.168.3.977
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJournal of Immunology
melbourne.source.volume168
melbourne.source.issue3
melbourne.source.pages977-980
melbourne.publicationid75690
melbourne.elementsid287193
melbourne.contributor.authorMintern, Justine
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorBelz, Gabrielle
melbourne.contributor.authorHeath, William
melbourne.contributor.authorDavey, Gayle
dc.identifier.eissn1550-6606
melbourne.accessrightsThis item is currently not available from this repository


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