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    Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection

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    Author
    Stock, AT; Mueller, SN; van Lint, AL; Heath, WR; Carbone, FR
    Date
    2004-08-15
    Source Title
    JOURNAL OF IMMUNOLOGY
    Publisher
    AMER ASSOC IMMUNOLOGISTS
    University of Melbourne Author/s
    STOCK, ANGUS THOMAS; MUELLER, SCOTT NORMAN; Carbone, Francis; Heath, William; Mueller, Scott; VAN LINT, ALLISON LOUISE
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Stock, A. T., Mueller, S. N., van Lint, A. L., Heath, W. R. & Carbone, F. R. (2004). Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection. JOURNAL OF IMMUNOLOGY, 173 (4), pp.2241-2244. https://doi.org/10.4049/jimmunol.173.4.2241.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26513
    DOI
    10.4049/jimmunol.173.4.2241
    Description

    C1 - Journal Articles Refereed

    Abstract
    It has been reported that MHC class I-restricted Ag presentation persists for only a short period following infection with certain pathogens, declining in parallel with the emergence of specific CTL activity. We have examined this issue in the case of murine infection with HSV-1. We found that the period of Ag presentation capable of priming naive CD8(+) T cells is comparatively prolonged, persisting for at least 7 days after infection, and continuing despite the appearance of localized CTL activity. Ag presentation was abbreviated to 3 or 4 days postinfection by surgical excision of the inoculation site early after infection. This intervention attenuated the size of the primary CTL response, implying that prolonged presentation is necessary to drive maximal CTL expansion. Combined, these data show that, in some types of infection, CTL priming can extend well beyond the first 24-48 h after primary inoculation.
    Keywords
    Cellular Immunology; Immune System and Allergy

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