Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection
AuthorStock, AT; Mueller, SN; van Lint, AL; Heath, WR; Carbone, FR
Source TitleJOURNAL OF IMMUNOLOGY
PublisherAMER ASSOC IMMUNOLOGISTS
University of Melbourne Author/sSTOCK, ANGUS THOMAS; MUELLER, SCOTT NORMAN; Carbone, Francis; Heath, William; Mueller, Scott; VAN LINT, ALLISON LOUISE
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsStock, A. T., Mueller, S. N., van Lint, A. L., Heath, W. R. & Carbone, F. R. (2004). Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection. JOURNAL OF IMMUNOLOGY, 173 (4), pp.2241-2244. https://doi.org/10.4049/jimmunol.173.4.2241.
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C1 - Journal Articles Refereed
It has been reported that MHC class I-restricted Ag presentation persists for only a short period following infection with certain pathogens, declining in parallel with the emergence of specific CTL activity. We have examined this issue in the case of murine infection with HSV-1. We found that the period of Ag presentation capable of priming naive CD8(+) T cells is comparatively prolonged, persisting for at least 7 days after infection, and continuing despite the appearance of localized CTL activity. Ag presentation was abbreviated to 3 or 4 days postinfection by surgical excision of the inoculation site early after infection. This intervention attenuated the size of the primary CTL response, implying that prolonged presentation is necessary to drive maximal CTL expansion. Combined, these data show that, in some types of infection, CTL priming can extend well beyond the first 24-48 h after primary inoculation.
KeywordsCellular Immunology; Immune System and Allergy
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