Show simple item record

dc.contributor.authorMueller, SN
dc.contributor.authorJones, CM
dc.contributor.authorSmith, CM
dc.contributor.authorHeath, WR
dc.contributor.authorCarbone, FR
dc.date.available2014-05-21T19:36:01Z
dc.date.issued2002-03-04
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176110300013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationMueller, S. N., Jones, C. M., Smith, C. M., Heath, W. R. & Carbone, F. R. (2002). Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus. JOURNAL OF EXPERIMENTAL MEDICINE, 195 (5), pp.651-656. https://doi.org/10.1084/jem.20012023.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/26515
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractLocalized cutaneous herpes simplex virus type 1 (HSV-1) infection leads to arming and initial expansion of cytotoxic T lymphocytes (CTLs) in the draining popliteal lymph nodes (PLNs) followed by migration and further proliferation in the spleen. To accurately characterize the sequence of events involved in the activation and generation of anti-HSV CTLs, we used T cell receptor (TCR) transgenic mice specific for the immunodominant epitope from HSV glycoprotein B (gB(498-505)). We describe the detection of the initiation of antigen presentation in the draining lymph nodes by 4-6 h after infection with HSV-1. Analysis of CD69 up-regulation revealed activation of gB-specific CD8(+) T cells by 6-8 h after infection. Furthermore, we show that T cell proliferation begins no sooner than 24 h after activation and is marked by the concurrent appearance of CTL activity in the PLNs. These events are not dependent on the presence of virus in the draining lymph nodes, and suggest a requirement for recruitment of professional antigen-presenting cells to the site of T cell activation. Consequently, we have defined the initiation of the CD8(+) T cell-mediated response to cutaneous HSV-1 infection, demonstrating that the immune response to localized viral infection depends only on the appearance of cells presenting virus-derived antigen and commences with remarkable swiftness.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleRapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20012023
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF EXPERIMENTAL MEDICINE
melbourne.source.volume195
melbourne.source.issue5
melbourne.source.pages651-656
dc.research.coderfcd320202
dc.research.codeseo1998730102
dc.rights.licenseCC BY-NC-SA
melbourne.publicationid8877
melbourne.elementsid251303
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193766
melbourne.contributor.authorMUELLER, SCOTT NORMAN
melbourne.contributor.authorJONES, CLAERWEN
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorHeath, William
melbourne.contributor.authorMueller, Scott
melbourne.contributor.authorSMITH, CHRISTOPHER MICHAEL
dc.identifier.eissn1540-9538
melbourne.accessrightsAccess this item via the Open Access location


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record