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    Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.

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    Author
    Ghanizadeh, A; Berk, M
    Date
    2013-06-06
    Source Title
    Medical Gas Research
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Berk, Michael
    Affiliation
    Psychiatry
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Ghanizadeh, A. & Berk, M. (2013). Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.. Med Gas Res, 3 (1), pp.11-. https://doi.org/10.1186/2045-9912-3-11.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/265463
    DOI
    10.1186/2045-9912-3-11
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680337
    Abstract
    Hydrogen gas is a bioactive molecule that has a diversity of effects, including anti-apoptotic, anti-inflammatory and anti-oxidative properties; these overlap with the process of neuroprogression in major psychiatric disorders. Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. Moreover, lithium which is commonly administered for treating bipolar disorder has effects on oxidative stress and apoptotic pathways, as do valproate and some atypical antipsychotics for treating schizophrenia. Molecular hydrogen has been studied pre-clinically in animal models for the treatment of some medical conditions including hypoxia and neurodegenerative disorders, and there are intriguing clinical findings in neurological disorders including Parkinson's disease. Therefore, it is hypothesized that administration of hydrogen molecule may have potential as a novel therapy for bipolar disorder, schizophrenia, and other concurrent disorders characterized by oxidative, inflammatory and apoptotic dysregulation.

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