Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999-2000
AuthorTribe, DE; Zaia, AM; Griffith, JM; Robinson, PM; Li, HY; Taylor, KN; Hogg, GG
Source TitleEPIDEMIOLOGY AND INFECTION
PublisherCAMBRIDGE UNIV PRESS
University of Melbourne Author/sTribe, David; LI, HUA; HOGG, GEOFFREY; GRIFFITH, JULIA; ZAIA, ANGELO
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsTribe, D. E., Zaia, A. M., Griffith, J. M., Robinson, P. M., Li, H. Y., Taylor, K. N. & Hogg, G. G. (2002). Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999-2000. EPIDEMIOLOGY AND INFECTION, 128 (1), pp.7-14. https://doi.org/10.1017/S0950268801006343.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869797
C1 - Journal Articles Refereed
In the years 1999-2000, there was an increase in the incidence of meningococcal disease in Victoria, largely caused by Neisseria meningitidis serogroup C. This change was associated with a shift in age distribution of cases, with relatively more disease appearing in the 15-29 year age group, and with 40/58 serogroup C isolates in 2000 exhibiting a new macrorestriction pattern (pattern A). Thirty-four of 52 pattern A isolates tested displayed the novel phenotype C:2a:P1.4, and were consistently porA VR type P1.7-2,4 by DNA sequencing. Nine of 10 representative pattern A isolates analysed displayed a housekeeping gene allele profile (ST-11) that is characteristic of the electrophoretic type (ET)-15 variant that has caused outbreaks in Canada, the Czech Republic and Greece. Meningococci belonging to the ST-11 complex that were isolated in Victoria prior to 1999 did not display either restriction pattern A or PorA VR type P1.7-2,4.
KeywordsBiotechnology not elsewhere classified ; Biological Sciences
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