The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis
AuthorClements, CS; Reid, HH; Beddoe, T; Tynan, FE; Perugini, MA; Johns, TG; Bernard, CCA; Rossjohn, J
Source TitleProceedings of the National Academy of Sciences of USA
PublisherNATL ACAD SCIENCES
University of Melbourne Author/sPerugini, Matthew; JOHNS, TERRY; CLEMENTS, CRAIG STEVEN; BEDDOE, TRAVIS CLARKE
AffiliationMedicine - Austin Health And Northern Health
Document TypeJournal Article
CitationsClements, C. S., Reid, H. H., Beddoe, T., Tynan, F. E., Perugini, M. A., Johns, T. G., Bernard, C. C. A. & Rossjohn, J. (2003). The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100 (19), pp.11059-11064. https://doi.org/10.1073/pnas.1833158100.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC196926
C1 - Journal Articles Refereed
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. To gain new insights into the physiological and immunopathological role of MOG, we determined the 1.8-A crystal structure of the MOG extracellular domain (MOGED). MOGED adopts a classical Ig (Ig variable domain) fold that was observed to form an antiparallel head-to-tail dimer. A dimeric form of native MOG was observed, and MOGED was also shown to dimerize in solution, consistent with the view of MOG acting as a homophilic adhesion receptor. The MOG35-55 peptide, a major encephalitogenic determinant recognized by both T cells and demyelinating autoantibodies, is partly occluded within the dimer interface. The structure of this key autoantigen suggests a relationship between the dimeric form of MOG within the myelin sheath and a breakdown of immunological tolerance to MOG that is observed in multiple sclerosis.
KeywordsBiochemistry and Cell Biology not elsewhere classified ; Biological Sciences
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