Innate secretory antibodies protect against natural Salmonella typhimurium infection
Author
Wijburg, OLC; Uren, TK; Simpfendorfer, K; Johansen, FE; Brandtzaeg, P; Strugnell, RADate
2006-01-23Source Title
JOURNAL OF EXPERIMENTAL MEDICINEPublisher
ROCKEFELLER UNIV PRESSUniversity of Melbourne Author/s
Wijburg, Odilia; SIMPFENDORFER, KIM; Strugnell, Richard; UREN, TANIAAffiliation
Microbiology And ImmunologyMetadata
Show full item recordDocument Type
Journal ArticleCitations
Wijburg, O. L. C., Uren, T. K., Simpfendorfer, K., Johansen, F. E., Brandtzaeg, P. & Strugnell, R. A. (2006). Innate secretory antibodies protect against natural Salmonella typhimurium infection. JOURNAL OF EXPERIMENTAL MEDICINE, 203 (1), pp.21-26. https://doi.org/10.1084/jem.20052093.Access Status
Access this item via the Open Access locationOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118088Description
C1 - Journal Articles Refereed
Abstract
The production of IgA is induced in an antigen-unspecific manner by commensal flora. These secretory antibodies (SAbs) may bind multiple antigens and are thought to eliminate commensal bacteria and self-antigens to avoid systemic recognition. In this study, we addressed the role of "innate" SAbs, i.e., those that are continuously produced in normal individuals, in protection against infection of the gastrointestinal tract. We used polymeric immunoglobulin receptor (pIgR-/-) knock-out mice, which are unable to bind and actively transport dimeric IgA and pentameric IgM to the mucosae, and examined the role of innate SAbs in protection against the invasive pathogen Salmonella typhimurium. In vitro experiments suggested that innate IgA in pIgR-/- serum bound S. typhimurium in a cross-reactive manner which inhibited epithelial cell invasion. Using a "natural" infection model, we demonstrated that pIgR-/- mice are profoundly sensitive to infection with S. typhimurium via the fecal-oral route and, moreover, shed more bacteria that readily infected other animals. These results imply an important evolutionary role for innate SAbs in protecting both the individual and the herd against infections, and suggest that the major role of SAbs may be to prevent the spread of microbial pathogens throughout the population, rather than protection of local mucosal surfaces.
Keywords
Humoral Immunology and Immunochemistry; Immune System and AllergyExport Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References