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dc.contributor.authorSutton, P
dc.contributor.authorDanon, SJ
dc.contributor.authorWalker, M
dc.contributor.authorThompson, LJ
dc.contributor.authorWilson, J
dc.contributor.authorKosaka, T
dc.contributor.authorLee, A
dc.date.available2014-05-21T19:40:06Z
dc.date.issued2001-10-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171229100005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationSutton, P., Danon, S. J., Walker, M., Thompson, L. J., Wilson, J., Kosaka, T. & Lee, A. (2001). Post-immunisation gastritis and Helicobacter infection in the mouse: a long term study. GUT, 49 (4), pp.467-473. https://doi.org/10.1136/gut.49.4.467.
dc.identifier.issn0017-5749
dc.identifier.urihttp://hdl.handle.net/11343/26608
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractBACKGROUND AND AIMS: Helicobacter pylori is a major cause of peptic ulcers and gastric cancer. Vaccine development is progressing but there is concern that immunisation may exacerbate Helicobacter induced gastritis: prophylactic immunisation followed by challenge with H felis or H pylori can induce a more severe gastritis in mice than seen with infection alone. The aim of this study was to investigate the relationship between immunity to Helicobacter infection and post-immunisation gastritis. METHODS: (1) C57BL/6 mice were prophylactically immunised before challenge with either H felis or H pylori. Histopathology and colonisation were assessed one month post-challenge. (2) C57BL/6 mice were prophylactically immunised against H felis infection and gastritis assessed up to 18 months post-challenge. RESULTS: Prophylactic immunisation induced a reduction in bacterial colonisation following H felis challenge which was associated with increased severity of active gastritis with neutrophil infiltration and atrophy. However, immunised mice challenged with H pylori SS1 had little evidence of pathology. Long term follow up showed that post-immunisation gastritis was evident at three months. However, from six months onwards, although immunised/challenged mice still developed gastritis, there was no significant difference between inflammation in these mice and infected controls. Post-immunisation gastritis was not associated with the serum antibody response. Immunisation prevented the formation of secondary lymphoid aggregates in the gastric tissue. CONCLUSION: The H felis mouse model of post-immunisation gastritis is the most extreme example of this type of pathology. We have shown in this model that post-immunisation gastritis is a transient event which does not produce long term exacerbation of pathology.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherBRITISH MED JOURNAL PUBL GROUP
dc.subjectImmunology not elsewhere classified; Prevention - Biologicals (e.g. Vaccines)
dc.titlePost-immunisation gastritis and Helicobacter infection in the mouse: a long term study
dc.typeJournal Article
dc.identifier.doi10.1136/gut.49.4.467
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentVeterinary Science
melbourne.source.titleGUT
melbourne.source.volume49
melbourne.source.issue4
melbourne.source.pages467-473
dc.research.coderfcd320299
dc.research.codeseo1998670401
melbourne.publicationid76516
melbourne.elementsid287749
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1728471
melbourne.contributor.authorSutton, Philip
dc.identifier.eissn1468-3288
melbourne.accessrightsAccess this item via the Open Access location


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