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    Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam

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    Author
    Toan, NL; Song, LH; Kremsner, PG; Duy, DN; Binh, VQ; Koeberlein, B; Kaiser, S; Kandolf, R; Torresi, J; Bock, C-T
    Date
    2006-06-01
    Source Title
    HEPATOLOGY
    Publisher
    WILEY
    University of Melbourne Author/s
    Torresi, Joseph
    Affiliation
    Medicine - Royal Melbourne And Western Hospitals
    Metadata
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    Document Type
    Journal Article
    Citations
    Toan, N. L., Song, L. H., Kremsner, P. G., Duy, D. N., Binh, V. Q., Koeberlein, B., Kaiser, S., Kandolf, R., Torresi, J. & Bock, C. -T. (2006). Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam. HEPATOLOGY, 43 (6), pp.1375-1384. https://doi.org/10.1002/hep.21188.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26611
    DOI
    10.1002/hep.21188
    Description

    C1 - Journal Articles Refereed

    Abstract
    Eight genotypes (A-H) of hepatitis B virus (HBV) have been identified. However, the impact of different genotypes on the clinical course of hepatitis B infection remains controversial. We investigated the frequency and clinical outcome of HBV genotypes and genotype mixtures in HBV-infected patients from Vietnam, Europe, and Africa. In addition, we analyzed the effects of genotype mixtures on alterations in in vitro viral replication. In Asian patients, seven genotypes (A-G) were detected, with A, C, and D predominating. In European and African patients, only genotypes A, C, D, and G were identified. Genotype mixtures were more frequently encountered in African than in Asian (P = .01) and European patients (P = .06). In Asian patients, the predominant genotype mixtures included A/C and C/D, compared to C/D in European and A/D in African patients. Genotype A was more frequent in asymptomatic compared with symptomatic patients (P < .0001). Genotype C was more frequent in patients with hepatocellular carcinoma (HCC; P = .02). Genotype mixtures were more frequently encountered in patients with chronic hepatitis in comparison to patients with acute hepatitis B (P = .015), liver cirrhosis (P = .013), and HCC (P = .002). Viral loads in patients infected with genotype mixtures were significantly higher in comparison to patients with a single genotype (P = .019). Genotype mixtures were also associated with increased in vitro HBV replication. In conclusion, infection with mixtures of HBV genotypes is frequent in Asia, Africa, and Europe. Differences in the replication-phenotype of single genotypes compared to genotype-mixtures suggest that co-infection with different HBV-genotypes is associated with altered pathogenesis and clinical outcome.
    Keywords
    Infectious Diseases; Infectious Diseases

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