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dc.contributor.authorToan, NL
dc.contributor.authorSong, LH
dc.contributor.authorKremsner, PG
dc.contributor.authorDuy, DN
dc.contributor.authorBinh, VQ
dc.contributor.authorKoeberlein, B
dc.contributor.authorKaiser, S
dc.contributor.authorKandolf, R
dc.contributor.authorTorresi, J
dc.contributor.authorBock, C-T
dc.identifier.citationToan, N. L., Song, L. H., Kremsner, P. G., Duy, D. N., Binh, V. Q., Koeberlein, B., Kaiser, S., Kandolf, R., Torresi, J. & Bock, C. -T. (2006). Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam. HEPATOLOGY, 43 (6), pp.1375-1384.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractEight genotypes (A-H) of hepatitis B virus (HBV) have been identified. However, the impact of different genotypes on the clinical course of hepatitis B infection remains controversial. We investigated the frequency and clinical outcome of HBV genotypes and genotype mixtures in HBV-infected patients from Vietnam, Europe, and Africa. In addition, we analyzed the effects of genotype mixtures on alterations in in vitro viral replication. In Asian patients, seven genotypes (A-G) were detected, with A, C, and D predominating. In European and African patients, only genotypes A, C, D, and G were identified. Genotype mixtures were more frequently encountered in African than in Asian (P = .01) and European patients (P = .06). In Asian patients, the predominant genotype mixtures included A/C and C/D, compared to C/D in European and A/D in African patients. Genotype A was more frequent in asymptomatic compared with symptomatic patients (P < .0001). Genotype C was more frequent in patients with hepatocellular carcinoma (HCC; P = .02). Genotype mixtures were more frequently encountered in patients with chronic hepatitis in comparison to patients with acute hepatitis B (P = .015), liver cirrhosis (P = .013), and HCC (P = .002). Viral loads in patients infected with genotype mixtures were significantly higher in comparison to patients with a single genotype (P = .019). Genotype mixtures were also associated with increased in vitro HBV replication. In conclusion, infection with mixtures of HBV genotypes is frequent in Asia, Africa, and Europe. Differences in the replication-phenotype of single genotypes compared to genotype-mixtures suggest that co-infection with different HBV-genotypes is associated with altered pathogenesis and clinical outcome.
dc.subjectInfectious Diseases; Infectious Diseases
dc.titleImpact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne And Western Hospitals
melbourne.contributor.authorTorresi, Joseph
melbourne.accessrightsThis item is currently not available from this repository

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