Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient
AuthorGouskos, T; Wightman, F; Chang, J; Earnest-Silveira, L; Sasadeusz, J; Lewis, SR; Torresi, J
PublisherLIPPINCOTT WILLIAMS & WILKINS
University of Melbourne Author/sEarnest, Linda; Sasadeusz, Joseph; Torresi, Joseph; Lewin, Sharon; GOUSKOS, THEO; WIGHTMAN, FIONA
AffiliationMedicine - Royal Melbourne And Western Hospitals
Document TypeJournal Article
CitationsGouskos, T., Wightman, F., Chang, J., Earnest-Silveira, L., Sasadeusz, J., Lewis, S. R. & Torresi, J. (2004). Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient. AIDS, 18 (12), pp.1734-1737. https://doi.org/10.1097/01.aids.0000131384.53350.59.
Access StatusThis item is currently not available from this repository
C5 - Other Refereed Contribution to Refereed Journals
We describe here a severe flare of hepatitis caused by lamivudine-resistant hepatitis B virus(HBV) in an HIV/HBV co-infected individual.Lamivudine-resistant HBV was detected 6 months before the development of severe hepatitis. Sequencing of the HBV genome isolated from the patients' serum did not identify compensatory mutations in the HBV polymerase that may have restored viral replication. However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis.
KeywordsInfectious Diseases; Infectious Diseases
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