Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient

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    Author
    Gouskos, T; Wightman, F; Chang, J; Earnest-Silveira, L; Sasadeusz, J; Lewis, SR; Torresi, J
    Date
    2004-08-20
    Source Title
    AIDS
    Publisher
    LIPPINCOTT WILLIAMS & WILKINS
    University of Melbourne Author/s
    Earnest, Linda; Sasadeusz, Joseph; Torresi, Joseph; Lewin, Sharon; GOUSKOS, THEO; WIGHTMAN, FIONA
    Affiliation
    Medicine - Royal Melbourne And Western Hospitals
    Metadata
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    Document Type
    Journal Article
    Citations
    Gouskos, T., Wightman, F., Chang, J., Earnest-Silveira, L., Sasadeusz, J., Lewis, S. R. & Torresi, J. (2004). Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient. AIDS, 18 (12), pp.1734-1737. https://doi.org/10.1097/01.aids.0000131384.53350.59.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26613
    DOI
    10.1097/01.aids.0000131384.53350.59
    Description

    C5 - Other Refereed Contribution to Refereed Journals
    Abstract
    We describe here a severe flare of hepatitis caused by lamivudine-resistant hepatitis B virus(HBV) in an HIV/HBV co-infected individual.Lamivudine-resistant HBV was detected 6 months before the development of severe hepatitis. Sequencing of the HBV genome isolated from the patients' serum did not identify compensatory mutations in the HBV polymerase that may have restored viral replication. However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis.
    Keywords
    Infectious Diseases; Infectious Diseases

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