Differential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections
Author
Crowe, SR; Turner, SJ; Miller, SC; Roberts, AD; Rappolo, RA; Doherty, PC; Ely, KH; Woodland, DLDate
2003-08-04Source Title
JOURNAL OF EXPERIMENTAL MEDICINEPublisher
ROCKEFELLER UNIV PRESSAffiliation
Microbiology And ImmunologyMetadata
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Journal ArticleCitations
Crowe, S. R., Turner, S. J., Miller, S. C., Roberts, A. D., Rappolo, R. A., Doherty, P. C., Ely, K. H. & Woodland, D. L. (2003). Differential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections. JOURNAL OF EXPERIMENTAL MEDICINE, 198 (3), pp.399-410. https://doi.org/10.1084/jem.20022151.Access Status
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194086Description
C1 - Journal Articles Refereed
Abstract
The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366-374/Db- and PA224-233/Db-specific CD8+ T cells respond in approximately equal numbers to a primary influenza virus infection in C57BL/6 mice, whereas NP366-374/Db-specific CD8+ T cells dominate the secondary response. To investigate the mechanisms underlying this changing pattern of immunodominance, we analyzed the role of antigen presentation in regulating the specificity of the T cell response. The data show that both dendritic and nondendritic cells are able to present the NP366-374/Db epitope, whereas only dendritic cells effectively present the PA224-233/Db epitope after influenza virus infection, both in vitro and in vivo. This difference in epitope expression favored the activation and expansion of NP366-374/Db-specific CD8+ memory T cells during secondary infection. The data also show that the immune response to influenza virus infection may involve T cells specific for epitopes, such as PA224-233/Db, that are poorly expressed at the site of infection. In this regard, vaccination with the PA224-233 peptide actually had a detrimental effect on the clearance of a subsequent influenza virus infection. Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies.
Keywords
Cellular Immunology; Immune System and AllergyExport Reference in RIS Format
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