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dc.contributor.authorCrowe, SR
dc.contributor.authorTurner, SJ
dc.contributor.authorMiller, SC
dc.contributor.authorRoberts, AD
dc.contributor.authorRappolo, RA
dc.contributor.authorDoherty, PC
dc.contributor.authorEly, KH
dc.contributor.authorWoodland, DL
dc.date.available2014-05-21T19:40:30Z
dc.date.issued2003-08-04
dc.identifierpii: jem.20022151
dc.identifier.citationCrowe, S. R., Turner, S. J., Miller, S. C., Roberts, A. D., Rappolo, R. A., Doherty, P. C., Ely, K. H. & Woodland, D. L. (2003). Differential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections. JOURNAL OF EXPERIMENTAL MEDICINE, 198 (3), pp.399-410. https://doi.org/10.1084/jem.20022151.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/26616
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366-374/Db- and PA224-233/Db-specific CD8+ T cells respond in approximately equal numbers to a primary influenza virus infection in C57BL/6 mice, whereas NP366-374/Db-specific CD8+ T cells dominate the secondary response. To investigate the mechanisms underlying this changing pattern of immunodominance, we analyzed the role of antigen presentation in regulating the specificity of the T cell response. The data show that both dendritic and nondendritic cells are able to present the NP366-374/Db epitope, whereas only dendritic cells effectively present the PA224-233/Db epitope after influenza virus infection, both in vitro and in vivo. This difference in epitope expression favored the activation and expansion of NP366-374/Db-specific CD8+ memory T cells during secondary infection. The data also show that the immune response to influenza virus infection may involve T cells specific for epitopes, such as PA224-233/Db, that are poorly expressed at the site of infection. In this regard, vaccination with the PA224-233 peptide actually had a detrimental effect on the clearance of a subsequent influenza virus infection. Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleDifferential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20022151
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF EXPERIMENTAL MEDICINE
melbourne.source.volume198
melbourne.source.issue3
melbourne.source.pages399-410
dc.research.coderfcd320202
dc.research.codeseo1998730102
dc.rights.licenseCC BY-NC-SA
melbourne.publicationid19219
melbourne.elementsid257677
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194086
melbourne.contributor.authorTurner, Stephen
melbourne.contributor.authorDoherty, Peter
dc.identifier.eissn1540-9538
melbourne.accessrightsAccess this item via the Open Access location


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