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dc.contributor.authorCrowe, SR
dc.contributor.authorTurner, SJ
dc.contributor.authorMiller, SC
dc.contributor.authorRoberts, AD
dc.contributor.authorRappolo, RA
dc.contributor.authorDoherty, PC
dc.contributor.authorEly, KH
dc.contributor.authorWoodland, DL
dc.identifierpii: jem.20022151
dc.identifier.citationCrowe, S. R., Turner, S. J., Miller, S. C., Roberts, A. D., Rappolo, R. A., Doherty, P. C., Ely, K. H. & Woodland, D. L. (2003). Differential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections. JOURNAL OF EXPERIMENTAL MEDICINE, 198 (3), pp.399-410.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366-374/Db- and PA224-233/Db-specific CD8+ T cells respond in approximately equal numbers to a primary influenza virus infection in C57BL/6 mice, whereas NP366-374/Db-specific CD8+ T cells dominate the secondary response. To investigate the mechanisms underlying this changing pattern of immunodominance, we analyzed the role of antigen presentation in regulating the specificity of the T cell response. The data show that both dendritic and nondendritic cells are able to present the NP366-374/Db epitope, whereas only dendritic cells effectively present the PA224-233/Db epitope after influenza virus infection, both in vitro and in vivo. This difference in epitope expression favored the activation and expansion of NP366-374/Db-specific CD8+ memory T cells during secondary infection. The data also show that the immune response to influenza virus infection may involve T cells specific for epitopes, such as PA224-233/Db, that are poorly expressed at the site of infection. In this regard, vaccination with the PA224-233 peptide actually had a detrimental effect on the clearance of a subsequent influenza virus infection. Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies.
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleDifferential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJournal of Experimental Medicine
dc.rights.licenseCC BY-NC-SA
melbourne.contributor.authorTurner, Stephen
melbourne.contributor.authorDoherty, Peter
melbourne.accessrightsAccess this item via the Open Access location

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