dc.contributor.author | Crowe, SR | |
dc.contributor.author | Turner, SJ | |
dc.contributor.author | Miller, SC | |
dc.contributor.author | Roberts, AD | |
dc.contributor.author | Rappolo, RA | |
dc.contributor.author | Doherty, PC | |
dc.contributor.author | Ely, KH | |
dc.contributor.author | Woodland, DL | |
dc.date.available | 2014-05-21T19:40:30Z | |
dc.date.issued | 2003-08-04 | |
dc.identifier | pii: jem.20022151 | |
dc.identifier.citation | Crowe, S. R., Turner, S. J., Miller, S. C., Roberts, A. D., Rappolo, R. A., Doherty, P. C., Ely, K. H. & Woodland, D. L. (2003). Differential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections. JOURNAL OF EXPERIMENTAL MEDICINE, 198 (3), pp.399-410. https://doi.org/10.1084/jem.20022151. | |
dc.identifier.issn | 0022-1007 | |
dc.identifier.uri | http://hdl.handle.net/11343/26616 | |
dc.description | C1 - Journal Articles Refereed | |
dc.description.abstract | The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366-374/Db- and PA224-233/Db-specific CD8+ T cells respond in approximately equal numbers to a primary influenza virus infection in C57BL/6 mice, whereas NP366-374/Db-specific CD8+ T cells dominate the secondary response. To investigate the mechanisms underlying this changing pattern of immunodominance, we analyzed the role of antigen presentation in regulating the specificity of the T cell response. The data show that both dendritic and nondendritic cells are able to present the NP366-374/Db epitope, whereas only dendritic cells effectively present the PA224-233/Db epitope after influenza virus infection, both in vitro and in vivo. This difference in epitope expression favored the activation and expansion of NP366-374/Db-specific CD8+ memory T cells during secondary infection. The data also show that the immune response to influenza virus infection may involve T cells specific for epitopes, such as PA224-233/Db, that are poorly expressed at the site of infection. In this regard, vaccination with the PA224-233 peptide actually had a detrimental effect on the clearance of a subsequent influenza virus infection. Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies. | |
dc.format | application/pdf | |
dc.language | English | |
dc.publisher | ROCKEFELLER UNIV PRESS | |
dc.subject | Cellular Immunology; Immune System and Allergy | |
dc.title | Differential antigen presentation regulates the changing patterns of CD8(+) T cell immunodominance in primary and secondary influenza virus infections | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1084/jem.20022151 | |
melbourne.peerreview | Peer Reviewed | |
melbourne.affiliation | The University of Melbourne | |
melbourne.affiliation.department | Microbiology And Immunology | |
melbourne.source.title | JOURNAL OF EXPERIMENTAL MEDICINE | |
melbourne.source.volume | 198 | |
melbourne.source.issue | 3 | |
melbourne.source.pages | 399-410 | |
dc.research.coderfcd | 320202 | |
dc.research.codeseo1998 | 730102 | |
dc.rights.license | CC BY-NC-SA | |
melbourne.publicationid | 19219 | |
melbourne.elementsid | 257677 | |
melbourne.openaccess.pmc | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194086 | |
melbourne.contributor.author | Turner, Stephen | |
melbourne.contributor.author | Doherty, Peter | |
dc.identifier.eissn | 1540-9538 | |
melbourne.accessrights | Access this item via the Open Access location | |