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    Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum

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    Author
    van Dooren, GG; Marti, M; Tonkin, CJ; Stimmler, LM; Cowman, AF; McFadden, GI
    Date
    2005-07-01
    Source Title
    MOLECULAR MICROBIOLOGY
    Publisher
    WILEY
    University of Melbourne Author/s
    VAN DOOREN, GIEL GODEFRIDUS; TONKIN, CHRISTOPHER JOHN; McFadden, Geoffrey; Cowman, Alan; STIMMLER, LUCIANA
    Affiliation
    Botany
    Metadata
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    Document Type
    Journal Article
    Citations
    van Dooren, G. G., Marti, M., Tonkin, C. J., Stimmler, L. M., Cowman, A. F. & McFadden, G. I. (2005). Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. MOLECULAR MICROBIOLOGY, 57 (2), pp.405-419. https://doi.org/10.1111/j.1365-2958.2005.04699.x.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26617
    DOI
    10.1111/j.1365-2958.2005.04699.x
    Description

    C1 - Journal Articles Refereed

    Abstract
    Plasmodium parasites are unicellular eukaryotes that undergo a series of remarkable morphological transformations during the course of a multistage life cycle spanning two hosts (mosquito and human). Relatively little is known about the dynamics of cellular organelles throughout the course of these transformations. Here we describe the morphology of three organelles (endoplasmic reticulum, apicoplast and mitochondrion) through the human blood stages of the parasite life cycle using fluorescent reporter proteins fused to organelle targeting sequences. The endoplasmic reticulum begins as a simple crescent-shaped organelle that develops into a perinuclear ring with two small protrusions, followed by transformation into an extensive reticulated network as the parasite enlarges. Similarly, the apicoplast and the mitochondrion grow from single, small, discrete organelles into highly branched structures in later-stage parasites. These branched structures undergo an ordered fission - apicoplast followed by mitochondrion - to create multiple daughter organelles that are apparently linked as pairs for packaging into daughter cells. This is the first in-depth examination of intracellular organelles in live parasites during the asexual life cycle of this important human pathogen.
    Keywords
    Biochemistry and Cell Biology not elsewhere classified ; Infectious Agents; Medical Parasitology ; Infectious Diseases

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