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dc.contributor.authorvan Dooren, GG
dc.contributor.authorMarti, M
dc.contributor.authorTonkin, CJ
dc.contributor.authorStimmler, LM
dc.contributor.authorCowman, AF
dc.contributor.authorMcFadden, GI
dc.identifierpii: MMI4699
dc.identifier.citationvan Dooren, G. G., Marti, M., Tonkin, C. J., Stimmler, L. M., Cowman, A. F. & McFadden, G. I. (2005). Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. MOLECULAR MICROBIOLOGY, 57 (2), pp.405-419.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractPlasmodium parasites are unicellular eukaryotes that undergo a series of remarkable morphological transformations during the course of a multistage life cycle spanning two hosts (mosquito and human). Relatively little is known about the dynamics of cellular organelles throughout the course of these transformations. Here we describe the morphology of three organelles (endoplasmic reticulum, apicoplast and mitochondrion) through the human blood stages of the parasite life cycle using fluorescent reporter proteins fused to organelle targeting sequences. The endoplasmic reticulum begins as a simple crescent-shaped organelle that develops into a perinuclear ring with two small protrusions, followed by transformation into an extensive reticulated network as the parasite enlarges. Similarly, the apicoplast and the mitochondrion grow from single, small, discrete organelles into highly branched structures in later-stage parasites. These branched structures undergo an ordered fission - apicoplast followed by mitochondrion - to create multiple daughter organelles that are apparently linked as pairs for packaging into daughter cells. This is the first in-depth examination of intracellular organelles in live parasites during the asexual life cycle of this important human pathogen.
dc.subjectBiochemistry and Cell Biology not elsewhere classified ; Infectious Agents; Medical Parasitology ; Infectious Diseases
dc.titleDevelopment of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.source.titleMolecular Microbiology
melbourne.contributor.authorVAN DOOREN, GIEL GODEFRIDUS
melbourne.contributor.authorTONKIN, CHRISTOPHER JOHN
melbourne.contributor.authorMcFadden, Geoffrey
melbourne.contributor.authorCowman, Alan
melbourne.contributor.authorSTIMMLER, LUCIANA
melbourne.accessrightsThis item is currently not available from this repository

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