Vector Priming Reduces the Immunogenicity of Salmonella-Based Vaccines in Nramp1+/+ Mice

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    Author
    Vindurampulle, CJ; Attridge, SR
    Date
    2003-04
    Source Title
    Infection and Immunity
    Publisher
    American Society for Microbiology
    University of Melbourne Author/s
    VINDURAMPULLE, CHRISTOFER
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Vindurampulle, C. J. & Attridge, S. R. (2003). Vector Priming Reduces the Immunogenicity of Salmonella-Based Vaccines in Nramp1+/+ Mice. Infection and Immunity, 71 (4), pp.2258-2261. https://doi.org/10.1128/iai.71.4.2258-2261.2003.
    Access Status
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    URI
    http://hdl.handle.net/11343/26628
    DOI
    10.1128/iai.71.4.2258-2261.2003
    Description

    C1 - Journal Articles Refereed
    Abstract
    <jats:title>ABSTRACT</jats:title> <jats:p>The present studies in <jats:italic>Nramp1</jats:italic> <jats:sup>−/−</jats:sup> BALB/c and <jats:italic>Nramp1</jats:italic> <jats:sup>+/+</jats:sup> CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent <jats:italic>Salmonella</jats:italic> strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with <jats:italic>Salmonella enterica</jats:italic> serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.</jats:p>
    Keywords
    Bacteriology ; Biological Sciences

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