Vector Priming Reduces the Immunogenicity of Salmonella-Based Vaccines in Nramp1+/+ Mice
Author
Vindurampulle, CJ; Attridge, SRDate
2003-04Source Title
Infection and ImmunityPublisher
American Society for MicrobiologyUniversity of Melbourne Author/s
VINDURAMPULLE, CHRISTOFERAffiliation
Microbiology And ImmunologyMetadata
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Journal ArticleCitations
Vindurampulle, C. J. & Attridge, S. R. (2003). Vector Priming Reduces the Immunogenicity of Salmonella-Based Vaccines in Nramp1+/+ Mice. Infection and Immunity, 71 (4), pp.2258-2261. https://doi.org/10.1128/iai.71.4.2258-2261.2003.Access Status
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C1 - Journal Articles Refereed
Abstract
<jats:title>ABSTRACT</jats:title>
<jats:p>The present studies in <jats:italic>Nramp1</jats:italic>
<jats:sup>−/−</jats:sup> BALB/c and <jats:italic>Nramp1</jats:italic>
<jats:sup>+/+</jats:sup> CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent <jats:italic>Salmonella</jats:italic> strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with <jats:italic>Salmonella enterica</jats:italic> serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.</jats:p>
Keywords
Bacteriology ; Biological SciencesExport Reference in RIS Format
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