Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.

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    Author
    Vindurampulle, CJ; Attridge, SR
    Date
    2003-04
    Source Title
    Infection and Immunity
    Publisher
    American Society for Microbiology
    University of Melbourne Author/s
    VINDURAMPULLE, CHRISTOFER
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Vindurampulle, C. J. & Attridge, S. R. (2003). Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.. Infect Immun, 71 (4), pp.2258-2261. https://doi.org/10.1128/IAI.71.4.2258-2261.2003.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/26628
    DOI
    10.1128/IAI.71.4.2258-2261.2003
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152061
    Description

    C1 - Journal Articles Refereed
    Abstract
    The present studies in Nramp1(-/-) BALB/c and Nramp1(+/+) CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.
    Keywords
    Bacteriology ; Biological Sciences

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