Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.
AuthorVindurampulle, CJ; Attridge, SR
Source TitleInfection and Immunity
PublisherAmerican Society for Microbiology
University of Melbourne Author/sVINDURAMPULLE, CHRISTOFER
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsVindurampulle, C. J. & Attridge, S. R. (2003). Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.. Infect Immun, 71 (4), pp.2258-2261. https://doi.org/10.1128/IAI.71.4.2258-2261.2003.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC152061
C1 - Journal Articles Refereed
The present studies in Nramp1(-/-) BALB/c and Nramp1(+/+) CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.
KeywordsBacteriology ; Biological Sciences
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