Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.
Author
Jüttner, S; Cramer, T; Wessler, S; Walduck, A; Gao, F; Schmitz, F; Wunder, C; Weber, M; Fischer, SM; Schmidt, WE; ...Date
2003-11Source Title
Cellular MicrobiologyPublisher
WileyUniversity of Melbourne Author/s
WALDUCK, ANNAAffiliation
Microbiology And ImmunologyMetadata
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Journal ArticleCitations
Jüttner, S., Cramer, T., Wessler, S., Walduck, A., Gao, F., Schmitz, F., Wunder, C., Weber, M., Fischer, S. M., Schmidt, W. E., Wiedenmann, B., Meyer, T. F., Naumann, M. & Höcker, M. (2003). Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.. Cell Microbiol, 5 (11), pp.821-834. https://doi.org/10.1046/j.1462-5822.2003.00324.x.Access Status
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C1 - Journal Articles Refereed
Abstract
Cyclooxygenase-2 (COX-2) represents the inducible key enzyme of arachidonic acid metabolism and contributes to the pathogenesis of gastroduodenal ulcers and gastric cancer. Helicobacter pylori infection is associated with elevated gastric COX-2 levels, but the mechanisms underlying H. pylori-dependent cox-2 gene expression are unclear. H. pylori stimulated cox-2 mRNA and protein abundance in gastric epithelial cells in vitro and in vivo, and functional analysis of the cox-2 gene promoter mapped its H. pylori-responsive region to a proximal CRE/Ebox element at -56 to -48. Moreover, USF1/-2 and CREB transcription factors binding to this site were identified to transmit H. pylori-dependent cox-2 transcription. Activation of MEK/ERK1/-2 signalling by bacterial virulence factors located outside the H. pylori cag pathogenicity island (cagPAI) was found to mediate bacterial effects on the cox-2 promoter. Our study provides a detailed description of the molecular pathways underlying H. pylori-dependent cox-2 gene expression in gastric epithelial cells, and may thus contribute to a better understanding of mechanisms underlying H. pylori pathogenicity.
Keywords
Bacteriology ; Infectious Diseases; Infectious DiseasesExport Reference in RIS Format
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