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dc.contributor.authorJüttner, S
dc.contributor.authorCramer, T
dc.contributor.authorWessler, S
dc.contributor.authorWalduck, A
dc.contributor.authorGao, F
dc.contributor.authorSchmitz, F
dc.contributor.authorWunder, C
dc.contributor.authorWeber, M
dc.contributor.authorFischer, SM
dc.contributor.authorSchmidt, WE
dc.contributor.authorWiedenmann, B
dc.contributor.authorMeyer, TF
dc.contributor.authorNaumann, M
dc.contributor.authorHöcker, M
dc.identifierpii: 324
dc.identifier.citationJüttner, S., Cramer, T., Wessler, S., Walduck, A., Gao, F., Schmitz, F., Wunder, C., Weber, M., Fischer, S. M., Schmidt, W. E., Wiedenmann, B., Meyer, T. F., Naumann, M. & Höcker, M. (2003). Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.. Cell Microbiol, 5 (11), pp.821-834.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractCyclooxygenase-2 (COX-2) represents the inducible key enzyme of arachidonic acid metabolism and contributes to the pathogenesis of gastroduodenal ulcers and gastric cancer. Helicobacter pylori infection is associated with elevated gastric COX-2 levels, but the mechanisms underlying H. pylori-dependent cox-2 gene expression are unclear. H. pylori stimulated cox-2 mRNA and protein abundance in gastric epithelial cells in vitro and in vivo, and functional analysis of the cox-2 gene promoter mapped its H. pylori-responsive region to a proximal CRE/Ebox element at -56 to -48. Moreover, USF1/-2 and CREB transcription factors binding to this site were identified to transmit H. pylori-dependent cox-2 transcription. Activation of MEK/ERK1/-2 signalling by bacterial virulence factors located outside the H. pylori cag pathogenicity island (cagPAI) was found to mediate bacterial effects on the cox-2 promoter. Our study provides a detailed description of the molecular pathways underlying H. pylori-dependent cox-2 gene expression in gastric epithelial cells, and may thus contribute to a better understanding of mechanisms underlying H. pylori pathogenicity.
dc.subjectBacteriology ; Infectious Diseases; Infectious Diseases
dc.titleHelicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleCellular Microbiology
melbourne.contributor.authorWALDUCK, ANNA
melbourne.internal.ingestnoteAbstract bulk upload (2017-07-20)
melbourne.accessrightsThis item is currently not available from this repository

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