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dc.contributor.authorTan, S-S
dc.contributor.authorKalloniatis, M
dc.contributor.authorTruong, H-T
dc.contributor.authorBinder, MD
dc.contributor.authorCate, HS
dc.contributor.authorKilpatrick, TJ
dc.contributor.authorHammond, VE
dc.identifier.citationTan, S. -S., Kalloniatis, M., Truong, H. -T., Binder, M. D., Cate, H. S., Kilpatrick, T. J. & Hammond, V. E. (2009). Oligodendrocyte Positioning in Cerebral Cortex is Independent of Projection Neuron Layering. GLIA, 57 (9), pp.1024-1030.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe factors affecting normal oligodendrocyte positioning in the cerebral cortex are unknown. Apart from the white matter, the highest numbers of oligodendrocytes in the rodent cortex are found in Layers V/VI, where the infragranular neurons normally reside. Few, if any, oligodendrocytes are normally found in the superficial cortical layers. To test whether or not this asymmetric positioning of oligodendrocytes is linked to the lamina positions of Layer V/VI projection neurons, mutant mice that cause neuronal layer inversion were examined. In three lines of mutant mice (Reeler, disabled-1, and p35) examined, representing two different genetic signaling pathways, the oligodendrocyte distribution was altered from an asymmetric to a symmetric distribution pattern. Unlike cortical neurons that are inverted in these mutant mice, the lack of oligodendrocyte inversion suggests a decoupling of the genetic mechanisms governing neuronal versus oligodendrocyte patterning. We conclude that oligodendrocyte positioning is not linked to the layer positions of V/VI projection neurons.
dc.subjectCentral Nervous System; Cellular Nervous System; Central Nervous System ; Cellular Nervous System; Nervous System and Disorders; Nervous System and Disorders
dc.titleOligodendrocyte Positioning in Cerebral Cortex is Independent of Projection Neuron Layering
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine, Dentistry And Health Sciences
melbourne.contributor.authorTan, Seong
melbourne.contributor.authorBinder, Michele
melbourne.contributor.authorCate, Holly
melbourne.contributor.authorKilpatrick, Trevor
melbourne.contributor.authorHAMMOND, VICKI
melbourne.contributor.authorTRUONG, HUE-TRUNG
melbourne.fieldofresearch320903 Central nervous system
melbourne.fieldofresearch320902 Cellular nervous system
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository

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