University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Psychiatry
  • Psychiatry - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Psychiatry
  • Psychiatry - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    69
    57
    Author
    Takahashi, T; Wood, SJ; Soulsby, B; McGorry, PD; Tanino, R; Suzuki, M; Velakoulis, D; Pantelis, C
    Date
    2009-03-01
    Source Title
    SCHIZOPHRENIA RESEARCH
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    TAKAHASHI, TSUTOMU; SOULSBY, BRIDGET; McGorry, Patrick; Velakoulis, Dennis; Pantelis, Christos; Wood, Stephen
    Affiliation
    Psychiatry
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Takahashi, T., Wood, S. J., Soulsby, B., McGorry, P. D., Tanino, R., Suzuki, M., Velakoulis, D. & Pantelis, C. (2009). Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia. SCHIZOPHRENIA RESEARCH, 108 (1-3), pp.49-56. https://doi.org/10.1016/j.schres.2008.12.029.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26726
    DOI
    10.1016/j.schres.2008.12.029
    Description

    C1 - Journal Articles Refereed

    Abstract
    Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains unknown whether these abnormalities develop progressively over the course of the illness. In the current study, longitudinal magnetic resonance imaging data were obtained from 23 patients with first-episode psychosis (FEP), 11 patients with chronic schizophrenia, and 26 healthy controls. The volumes of the short (anterior) and long (posterior) insular cortices were measured on baseline and follow-up (between 1 and 4 years later) scans and were compared across groups. In cross-sectional comparison at baseline, the FEP and chronic schizophrenia patients had significantly smaller short insular cortex than did controls. In longitudinal comparison, the FEP patients showed significant gray matter reduction of the insular cortex over time (-4.3%/2.0 years) compared with controls (0.3%/2.2 years) without significant subregional effects, but there was no difference between chronic schizophrenia patients (-1.7%/2.4 years) and controls. The gray matter loss of the left insular cortex over time in FEP patients was correlated with the severity of positive and negative symptoms at follow-up. These findings indicate that patients with psychotic disorders have smaller gray matter volume of the insular cortex especially for its anterior portion (short insula) at first expression of overt psychosis, but also exhibit a regional progressive pathological process of the insular cortex during the early phase after the onset, which seems to reflect the subsequent symptomatology.
    Keywords
    Psychiatry (incl. Psychotherapy); Psychiatry ; Nervous System and Disorders; Nervous System and Disorders

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52443]
    • Psychiatry - Research Publications [1373]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors