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dc.contributor.authorShaktivesh
dc.date.accessioned2021-04-08T02:15:13Z
dc.date.available2021-04-08T02:15:13Z
dc.date.issued2020
dc.identifier.urihttp://hdl.handle.net/11343/268104
dc.description© 2020 Shaktivesh
dc.description.abstractThe damage to osteochondral tissue can develop degenerative joint diseases such as subchondral bone necrosis, osteochondral fracture, and osteoarthritis. In the development of these joint diseases, the subchondral bone plays a crucial role due to several risk factors: obesity, hereditary, aging, gender, and intense mechanical loads. The intense mechanical loads include both trauma/impact and repetitive loads which occur during high-intensity training and have been identified as the primary risk factor in the development of joint diseases. In this dissertation, we utilized mechanical tests combined with digital image correlation and micro-computed tomography to study the mechanical behaviour (in particular, Elastic Modulus and Energy Dissipation) of subchondral bone under both trauma/impact and repetitive loads. Results suggest that the presence of severe cartilage lesion in osteochondral tissue reduces the stiffness of cartilage and increases the compressive strain in the subchondral bone under trauma/impact loads. Moreover, the application of simulated physiological repetitive loads on subchondral bone has demonstrated the importance of the highest speeds in the development of the joint disease, consistent with the observations made in equine athletes. The results also exhibit the influence of microstructural properties on the mechanical behaviour of subchondral bone under repetitive loads. The results and approach of simulating physiological loading may be useful in optimizing training protocol and prevent joint diseases.
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dc.subjectSubchondral Bone
dc.subjectEquine third metacarpal Bone
dc.subjectImpact load
dc.subjectRepetitive load
dc.subjectFatigue
dc.subjectCrack
dc.subjectDamage
dc.subjectMechanical tests
dc.subjectMicro-Computed Tomography (Micro-CT)
dc.subjectDigital Image Correlation
dc.subjectBiomaterial
dc.titleMechanical behaviour of Subchondral Bone: Elastic Moduli and Energy Dissipation in Subchondral Bone under Impact and Repetitive Loads
dc.typePhD thesis
melbourne.affiliation.departmentBiomedical Engineering
melbourne.affiliation.facultyEngineering and Information Technology
melbourne.thesis.supervisornameVee Sin Lee
melbourne.contributor.authorShaktivesh
melbourne.thesis.supervisorothernameDavid Ackland
melbourne.thesis.supervisorothernameFatemeh Malekipour
melbourne.tes.fieldofresearch1400303 Biomechanical engineering
melbourne.tes.fieldofresearch2400302 Biomaterials
melbourne.accessrightsOpen Access


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