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dc.contributor.authorShepherd, R. K.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.contributor.authorPyman, B. C.en_US
dc.contributor.authorWebb, R. L.en_US
dc.contributor.authorMurray, M. T.en_US
dc.contributor.authorHoughton, M. E.en_US
dc.date.accessioned2014-05-21T19:50:14Z
dc.date.available2014-05-21T19:50:14Z
dc.date.issued1985en_US
dc.identifier881670766en_US
dc.identifier.citationShepherd, R. K., Clark, G. M., Pyman, B. C., Webb, R. L., Murray, M. T., & Houghton, M. E. (1985). Histopathology following electrode insertion and chronic electrical stimulation. In Cochlear implants (10th Anniversary Conference on Cochlear Implants), San Francisco.en_US
dc.identifier.urihttp://hdl.handle.net/11343/26817
dc.description.abstractWe have examined a number of safety issues associated with cochlear implants. This work has been primarily designed to evaluate the histopathological effects of intracochlear electrode implantation and chronic electrical stimulation. The results of these studies may be summarized as follows: 1) The insertion of the banded free-fit scala tympani array into human cadaver temporal bones produces minimal damage, occurring primarily to a localized region of the spiral ligament. This damage would not result in significant neural degeneration and thus, would not compromise the efficacy of the multiple channel device; 2) chronic intracochlear electrical stimulation for continuous periods of 500 to 2000 hours, using charge balanced biphasic current pulses developing charge densities of 18-32 }?C/cm2. geom./phase, does not adversely affect the spiral ganglion cell population; 3) labyrinthine infection severely reduces the viable spiral ganglion cell population; 4) the formation of new bone present in approximately half of the animals we have implanted --is not associated with electrical stimulation per se; 5) scanning electron microscope studies of electrodes subjected to long periods of intracochlear electrical stimulation reveals minimal platinum dissolution when compared with unstimulated control electrodes, and electrodes that have been stimulated for similar periods in inorganic saline.en_US
dc.publisherRaven Pressen_US
dc.relation.ispartofScientific publications, vol.3, 1984-1986, no.182en_US
dc.subjectcochlear implanten_US
dc.subjectelectrode arrayen_US
dc.subjectotolaryngologyen_US
dc.titleHistopathology following electrode insertion and chronic electrical stimulationen_US
dc.typeConference Paperen_US
melbourne.source.titleCochlear implants (10th Anniversary Conference on Cochlear Implants)en_US
melbourne.source.month22-24 Juneen_US
melbourne.source.pages65-81en_US
melbourne.source.locationconferenceSan Franciscoen_US
melbourne.source.editorSchindler, R. A.en_US
melbourne.source.editorMerzenich, M. Men_US
dc.description.sourcedateconference22-24 June 1983en_US
melbourne.elementsidNA
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorShepherd, Robert
melbourne.contributor.authorPYMAN, BRIAN
melbourne.accessrightsOpen Access


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