Rapid and permanent hearing loss in cats following co-administration of kanamycin and ethacrynic acid [Abstract]

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    Author
    Xu, Shi-Ang; Shepherd, Robert K.; Clark, Graeme M.
    Date
    1990
    Source Title
    Proceedings of the 51st Australian Physiological and Pharmacological Society
    University of Melbourne Author/s
    Clark, Graeme; Shepherd, Robert
    Metadata
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    Document Type
    Conference Item
    Citations
    Xu, S. A., Shepherd, R. K., & Clark, G. M. (1990). Rapid and permanent hearing loss in cats following co-administration of kanamycin and ethacrynic acid [Abstract]. In Proceedings of the 51st Australian Physiological and Pharmacological Society, Brisbane.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/26843
    Description

    This is an abstract of a paper from the Proceedings of the 51st Australian Physiological and Pharmacological Society, Brisbane, 17-20 April 1990, published by Australian Physiological and Pharmacological Society. This version is reproduced with the permission of publisher.
    Abstract
    A safe, simple and effective technique for producing profound-totally deaf animal models in both young and adult cats is required for auditory prosthesis related research. Exposure to loud noises can result in a partial hearing loss, the degree of which varies significantly among animals. Long-term systemic injection of an aminoglycoside ototoxic drug frequently results in renal dysfunction and can show significant variation in response among animals (Shepherd & Clark, 1985). Finally, direct infusion of ototoxic drugs produces extensive and highly variable cochlear pathology, unsuitable for auditory prosthesis research.
    Keywords
    otolaryngology; hearing loss

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