Human stem cells ameliorate auditory evoked responses in a model of neuropathy
Web of Science
Source TitleStem Cell Research and Therapy
PublisherBIOMED CENTRAL LTD
University of Melbourne Author/sNayagam, Bryony
AffiliationAudiology and Speech Pathology
Document TypeJournal Article
CitationsNayagam, B. A. (2012). Human stem cells ameliorate auditory evoked responses in a model of neuropathy. STEM CELL RESEARCH & THERAPY, 3 (6), https://doi.org/10.1186/scrt135.
Access StatusAccess this item via the Open Access location
Open Access URLPublished version
Stem cells have been touted as a potential source of replacement cells for the treatment of severe-to-profoundly deaf individuals, including possible combined therapy with a cochlear implant. The success of such a therapy is dependent on a number of factors, but of critical importance is the functional incorporation of transplanted cells into the peripheral and central auditory systems. In a major breakthrough, Chen and colleagues recently reported the restoration of hearing thresholds by up to 46% following the transplantation of human pluripotent stem cells in a rodent auditory neuropathy model. Improved function was matched with new synapse formation in the peripheral and central aspects of the auditory system. The findings have promising clinical implications for patients with auditory neuropathy. Still to be elucidated are the long-term survival and function of transplanted cells, the precise mechanism by which hearing is restored, and whether further improvement is possible when combined with electrical stimulation from a cochlear implant.
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