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dc.contributor.authorNayagam, BA
dc.date.accessioned2021-04-22T00:46:31Z
dc.date.available2021-04-22T00:46:31Z
dc.date.issued2012-11-08
dc.identifierpii: scrt135
dc.identifier.citationNayagam, B. A. (2012). Human stem cells ameliorate auditory evoked responses in a model of neuropathy. STEM CELL RESEARCH & THERAPY, 3 (6), https://doi.org/10.1186/scrt135.
dc.identifier.issn1757-6512
dc.identifier.urihttp://hdl.handle.net/11343/268678
dc.description.abstractStem cells have been touted as a potential source of replacement cells for the treatment of severe-to-profoundly deaf individuals, including possible combined therapy with a cochlear implant. The success of such a therapy is dependent on a number of factors, but of critical importance is the functional incorporation of transplanted cells into the peripheral and central auditory systems. In a major breakthrough, Chen and colleagues recently reported the restoration of hearing thresholds by up to 46% following the transplantation of human pluripotent stem cells in a rodent auditory neuropathy model. Improved function was matched with new synapse formation in the peripheral and central aspects of the auditory system. The findings have promising clinical implications for patients with auditory neuropathy. Still to be elucidated are the long-term survival and function of transplanted cells, the precise mechanism by which hearing is restored, and whether further improvement is possible when combined with electrical stimulation from a cochlear implant.
dc.languageEnglish
dc.publisherBIOMED CENTRAL LTD
dc.titleHuman stem cells ameliorate auditory evoked responses in a model of neuropathy
dc.typeJournal Article
dc.identifier.doi10.1186/scrt135
melbourne.affiliation.departmentAudiology and Speech Pathology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleStem Cell Research and Therapy
melbourne.source.volume3
melbourne.source.issue6
melbourne.elementsid374451
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC3580474?pdf=render
melbourne.openaccess.statusPublished version
melbourne.contributor.authorNayagam, Bryony
dc.identifier.eissn1757-6512
melbourne.accessrightsAccess this item via the Open Access location


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