Electrical stimulus induced changes in excitability of the auditory nerve
AuthorHuang, C. O.; Shepherd, Robert K.; Seligman, P. M.; Clark, Graeme M.
Source TitleProceedings of the Australian Neuroscience Society
Document TypeConference Item
CitationsHuang, C. O., Shepherd, R. K., Seligman, P. M., & Clark, G. M. (1997). Electrical stimulus induced changes in excitability of the auditory nerve. In Proceedings of the Australian Neuroscience Society, Newcastle.
Access StatusOpen Access
This is an abstract of a paper from Proceedings of the Australian Neuroscience Society 1997 published by Australian Neuroscience Society. This version is reproduced with the permission of publisher.
High rate electrical stimulation of the auditory nerve using stimulus intensities well above the clinical limits can induce a significant reduction in the excitability of the auditory nerve as measured by a decrement in the amplitude of the electrically evoked auditory brainstem response (EABR). Two potential mechanisms may be associated with this stimulus induced reduction in activity: 1) stimulus induced prolonged neuronal hyperactivity; and 2) the generation of adverse electrochemical productions from the electrode surface. The purpose of the present study was to assess the extent to which adverse electrochemical damage contributes to the stimulus induced reduction in auditory nerve excitability. Twenty-six adult guinea pigs anaesthetized with ketamine (40 mg/kg i.p.) and xylazine (4 mglkg i.p.), were bilaterally implanted and unilaterally stimulated for two hours using a stimulus intensity of two or four times EABR threshold. Stimulus rates of 200, 400, or 1000 pulses/s (pps) were delivered via a standard platinum scala tympani electrode or large surface area ("high Q") platinum electrode.
Keywordscochlear implants; electrical stimulation; otolaryngology
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- Graeme Clark Collection