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dc.contributor.authorBurkitt, A. N.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.date.accessioned2014-05-21T20:02:13Z
dc.date.available2014-05-21T20:02:13Z
dc.date.issued1999en_US
dc.identifier.citationBurkitt, A. N., & Clark, G. M. (1999). Modelling the response of neurons to auditory stimuli: differences between acoustical and electrical stimulation. In Biomedical Research in the 3rd Millennium. Proceedings of the Inaugural Conference of the Victorian chapter of the IEEE Engineering in Medicine and Biology Society, Caulfield, Victoria.en_US
dc.identifier.urihttp://hdl.handle.net/11343/27041
dc.description.abstractThere are significant differences in the responses of auditory nerves when they are stimulated acoustically (normal hearing situation) or electrically (with a cochlear implant). This paper addresses the underlying causes of these differences by studying the interspike interval histogram, the synchronization index, and the entrainment (degree of response to successive cycles of the stimulus). The new integrated-input technique is used to analyze the response to periodic synaptic input of integrate-and-fire neurons, in which the randomly arriving synaptic inputs are summed and an action potential is generated when the postsynaptic potential reaches threshold. The synaptic inputs in the model are a sinusoidally modulated inhomogeneous Poisson process, and each input generates a postsynaptic response that subsequently decays according to the membrane decay constant. The results provide a quantitative understanding of both the decrease of the synchronization index with increasing frequency of acoustical stimulation in the auditory pathway and the previously observed enhancement of synchronization in globular bushy cells of the cochlear nucleus. The differences in the responses of neurons in higher stages of the auditory pathway for acoustical and electrical stimulation may be accounted for by the differences in the degree of entrainment that they induce.en_US
dc.relation.ispartofScientific publications, vol.11, 1998-1999, no.1218en_US
dc.subjectotolaryngologyen_US
dc.subjectIntegrate-and-fire neuronsen_US
dc.subjectsynchronizationen_US
dc.subjectperiodic stimulationen_US
dc.titleModelling the response of neurons to auditory stimuli: differences between acoustical and electrical stimulationen_US
dc.typeConference Paperen_US
melbourne.source.titleBiomedical Research in the 3rd Millennium. Proceedings of the Inaugural Conference of the Victorian chapter of the IEEE Engineering in Medicine and Biology Societyen_US
melbourne.source.month22-23 Februaryen_US
melbourne.source.pages46-49en_US
melbourne.source.locationconferenceCaulfield, Victoriaen_US
melbourne.source.editorLithgow, B.en_US
melbourne.source.editorCosic, I.en_US
dc.description.sourcedateconference22-23 Februaryen_US
melbourne.elementsidNA
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorBurkitt, Anthony
melbourne.accessrightsOpen Access


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