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dc.contributor.authorGillespie, L. N.en_US
dc.contributor.authorMarzella, P. L.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.contributor.authorBartlett, P. F.en_US
dc.contributor.authorKilpatrick, T. J.en_US
dc.date.accessioned2014-05-21T20:02:23Z
dc.date.available2014-05-21T20:02:23Z
dc.date.issued1999en_US
dc.identifier.citationGillespie, L. N., Marzella, P. L., Clark, G. M., Bartlett, P. F., & Kilpatrick, T. J. (1999). Growth factors from different superfamilies act in synergy when promoting the survival of auditory neurones in vitro [Abstract]. In Proceedings of the Australian Neuroscience Society, Hobart.en_US
dc.identifier.urihttp://hdl.handle.net/11343/27044
dc.descriptionThis is an abstract of a paper from Proceedings of the Australian Neuroscience Society 1999 published by Australian Neuroscience Society. This version is reproduced with the permission of publisher.en_US
dc.description.abstractSeveral growth factor superfamilies have been implicated in normal inner ear development and in promoting auditory neurone survival. The neuronal promoting ability of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), leukemia inhibitory factor (LIF) and transforming growth factor ß-5 (TGF-ß5), alone and in combination, were evaluated in dissociated cell cultures of early postnatal rat auditory neurones. Rat pups were anaesthetised on ice and sacrificed by rapid decapitation, followed by removal of the cochleae under aseptic conditions. Here we provide evidence that synergistic relationships exist between growth factors from diverse superfamilies when promoting auditory neurone survival in vitro. Administered alone, all factors promoted survival of between 10-15% of initially plated neurones, with NT-3 the most potent of the factors. When used in combination, LIF + BDNF, NT-3 + TGF-ß5, and BDNF + TGF-ß5 all promoted auditory neurone survival in a synergistic fashion. In contrast, NT-3 + BDNF and LIP + TGF-ß5 displayed additive survival effects. These results suggest that growth factors may act by interdependent mechanisms when sustaining neuronal integrity, and that a combination of several growth factors may provide a better approach than single factor therapy when developing pharmacological therapies for the treatment of deafness.en_US
dc.relation.ispartofScientific publications, vol.11, 1998-1999, no.1228en_US
dc.subjectotolaryngologyen_US
dc.subjectauditory neuronesen_US
dc.subjectsafety studiesen_US
dc.titleGrowth factors from different superfamilies act in synergy when promoting the survival of auditory neurones in vitro [Abstract]en_US
dc.typeConference Itemen_US
melbourne.source.titleProceedings of the Australian Neuroscience Societyen_US
melbourne.source.volume10en_US
melbourne.source.pages179en_US
melbourne.source.locationconferenceHobarten_US
dc.description.sourcedateconference31 January - 3 Februaryen_US
melbourne.elementsidNA
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorGillespie, Lisa
melbourne.contributor.authorMARZELLA, PHILLIP
melbourne.accessrightsOpen Access


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