Melbourne Dental School - Research Publications
Now showing items 1-10 of 155
Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample
Recent research has examined associations between inflammation and mental health, and has increasingly focused on utilising younger samples to characterise the temporal relationship between inflammatory responses and the ...
Polymerisation of a T cell epitope with an immunostimulatory C3d peptide sequence enhances antigen specific T cell responses
The complement protein C3d and C3d derived peptides that bind CD21 are known to enhance immunity to co-immunised antigens. In this study we have synthesised the minimal CD21 binding sequence of C3d (1227LYNVEA 1232) as ...
Mass spectrometric analysis of gingival crevicular fluid biomarkers can predict periodontal disease progression
Background and Objective: Gingival crevicular fluid has been suggested as a possible source of biomarkers for periodontal disease progression. This paper describes a technique for the analysis of gingival crevicular fluid ...
Protein substrates of a novel secretion system are numerous in the bacteroidetes phylum and have in common a cleavable C-Terminal secretion signal, extensive post-translational modiﬁcation, and cell-surface attachment
(American Chemical Society (ACS), 2013)
The secretion of certain proteins in Porphyromonas gingivalis is dependent on a C-terminal domain (CTD). After secretion, the CTD is cleaved prior to extensive modification of the mature protein, probably with lipopolysaccharide, ...
Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses
(Public Library of Science (PLOS), 2014)
Porphyromonas gingivalis and Treponema denticola are strongly associated with chronic periodontitis. These bacteria have been co-localized in subgingival plaque and demonstrated to exhibit symbiosis in growth in vitro and ...
Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development
(Public Library of Science (PLOS), 2013)
Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. Porphyromonas gingivalis, Treponema denticola and ...
Maculatin 1.1 disrupts Staphylococcus aureus lipid membranes via a pore mechanism
(American Society for Microbiology, 2013)
Maculatin 1.1 (Mac1) showed potent activity against Staphylococcus aureus with an MIC of 7 _M. The mode of action of Mac1 was investigated by combining assays with S. aureus cells and lipid vesicles mimicking their membrane ...
Clinical isolates and laboratory reference Candida species and strains have varying abilities to form biofilms
Candida biofilms are a major virulence trait for this yeast. In this study, the biofilm-forming ability of the major medically important clinical and laboratory reference strains was compared. Biofilms were quantified using ...
Differential proteomic analysis of a polymicrobial biofilm
(American Chemical Society (ACS), 2012)
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia exist in a polymicrobial biofilm associated with chronic periodontitis. The aim of this study was to culture these three species as a polymicrobial ...
A bio-informatics study of the c25 cysteine protease family
(Scientific Research, 2012)
The oral pathogen Porphyromonas gingivalis is recognized as one of the major aetiological agents of chronic periodontitis. The gingipains, which are the principal virulence factors of P. gingivalis, are multi-domain proteins ...