Physiological and histopathological effects of chronic intracochlear electrical stimulation
AuthorShepherd, R. K.; Clark, Graeme M.; Black, R. C.
Source TitleMechanisms of Hearing
PublisherMonash University Press
Document TypeConference Paper
CitationsShepherd, R. K., Clark, G. M., & Black, R. C. (1983). Physiological and histopathological effects of chronic intracochlear electrical stimulation. In W. R. Webster & L. M. Aitkin (Ed.), Mechanisms of Hearing, pp. 200-205. Clayton: Monash University Press.
Access StatusOpen Access
This is a paper presented at a symposium on the Mechanisms of Hearing, held at Monash University, Melbourne, Australia from August 23-27, 1983. This version is reproduced with the permission of Monash University Press.
Direct and r.f. currents are known to result in destruction of neural tissue. However, it is now apparent that non-destructive electrical stimulation can be achieved by the use of biphasic pulsatile stimuli (Lilly, 1960; Mortimer et al., 1970; Hughes et al., 1980). Although maximum biologically safe stimulation regimes have yet to be clearly defined, the evidence of a number of investigators suggests that charge density per phase and charge injection per phase are important parameters when establishing biologically safe levels of electrical stimulation (Pudenz et al., 1975; Pudenz et al., 1977; Brown et al., 1977; Babb et al., 1977). Furthermore, considerable attention has been given to ensure that the stimulus is not producing adverse electrochemical reactions that could result in physical or toxic injury to the biological environment. Brummer et al. (1977) have defined the upper limit of electrochemically safe electrical stimulation for platinum electrodes as charge balanced biphasic pulses at a maximum charge density of 300 ?C/cm2 geom./phase.
Keywordsotolaryngology; electrical stimulation; biphasic pulsatile stimuli
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