Melbourne Dental School - Theses
Now showing items 1-10 of 62
An assessment for unique biomarker profiles in oral squamous cell carcinoma
Purpose: Biomarkers can be used to predict the incidence or outcome of disease. Currently there are no established biomarkers for oral squamous cell carcinoma (OSCC). Identification of these markers and molecular profiles ...
Characterization of the Porphyromonas gingivalis protein PG1881 and its roles in outer membrane vesicle biogenesis and biofilm formation
Porphyromonas gingivalis is a non-motile, Gram-negative coccobacillus, oral anaerobe that is implicated in chronic periodontitis, a polymicrobial inflammatory disease resulting in the destruction of the supporting tissues ...
Investigation of the role of Treponema denticola motility and uncharacterized protein TDE0659 in synergistic biofilm formation with Porphyromonas gingivalis
Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species such as Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia contribute to disease progression. ...
Host-pathogen interactions of porphyromonas gingivalis
Periodontal health is supported by various host immune defence mechanisms, which act in concert to maintain host-microbe homeostasis. However, breakdown of homeostasis can lead to the development of chronic periodontitis, ...
Investigations into the effects of head and neck radiotherapy and the potential anticariogenicity of casein phosphopeptide-amorphous calcium phosphate and stannous fluoride
Radiotherapy is the primary treatment modality for most head and neck cancers, in particular, nasopharyngeal carcinoma (NPC). The use of advanced radiotherapy techniques such as intensity modulated radiotherapy (IMRT) ...
Chronic oral Graft-versus-Host Disease: clinical risk factors and biochemical markers of disease activity
Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT), along with the associated immunosuppression required post transplant, is associated with several potentially debilitating long-term complications, one of ...
Enhancing remineralisation using casein phosphopeptide complexes
Casein phosphopeptide (CPP) complexes have been shown to promote remineralisation of dental tissues affected by dental caries. However, remineralisation takes time and can be limited by the delivery and composition of the ...
Biochemical characterisation of outer membrane vesicles from periodontal pathogens and their role in innate immunity
This project characterises and assesses the immunological effects of outer membrane vesicles (OMVs) produced by major periodontal pathogens Porphromonas gingivalis, Treponema denticola and Tannerella forsythia. An OMV ...
Comparative studies of demarcated hypomineralised lesions of dental enamel and their fluorescence properties
Demarcated hypomineralised lesions (DHL) of dental enamel are qualitative developmental defects including molar-incisor hypomineralisation (MIH), hypomineralised second primary molars (HSPM) as well as other demarcated ...
Characterisation of Candida albicans, Actinomyces naeslundii and Streptococcus mutans interaction and its role in promoting oral carcinogenesis
Candida albicans has been widely reported in the aetiology of oral cancer. However, the role of its interaction with members of the oral microbiome, such as Actinomyces naeslundii and Streptococcus mutans, in promoting ...