Melbourne Dental School - Theses
Now showing items 1-10 of 67
The effect of Treponema denticola on Porphyromonas gingivalis phenotypes and transcriptome
Chronic periodontitis is an inflammatory, bacterial biofilm-associated disease resulting in destruction of the tooth’s supporting tissues. The imminent progression of chronic periodontitis can be predicted by the levels ...
Oral cancer prediction using microRNA in oral swirls
Purpose: To study a clinically convenient sample type, oral swirls as a source of microRNA for analysis in oral disease states. Objectives: To study a panel of OSCC-associated microRNA, identified in next generation ...
Early childhood caries in Cambodia
Children in Cambodia have a severe burden of caries and data from the Cambodian national oral health survey reflect that four in five 6-year-old children have one or more pulpally involved teeth. One of the key features ...
The rectangular block implant: a novel implant design for the posterior atrophic ridge.
A horizontally oriented rectangular block implant (RBI) is proposed: - maximizing the use of the resorbed posterior ridge length and qualifying as a “short” implant, with a surface area equivalent to that of longer cylindrical ...
Implications for an ‘amalgamless’ profession: an Australian perspective
The Minamata Convention on Mercury has committed to a reduction and ultimate elimination in the production and use of mercury containing products. Any consequent 'phase-down' of dental amalgam will change the practice of ...
An assessment for unique biomarker profiles in oral squamous cell carcinoma
Purpose: Biomarkers can be used to predict the incidence or outcome of disease. Currently there are no established biomarkers for oral squamous cell carcinoma (OSCC). Identification of these markers and molecular profiles ...
Characterization of the Porphyromonas gingivalis protein PG1881 and its roles in outer membrane vesicle biogenesis and biofilm formation
Porphyromonas gingivalis is a non-motile, Gram-negative coccobacillus, oral anaerobe that is implicated in chronic periodontitis, a polymicrobial inflammatory disease resulting in the destruction of the supporting tissues ...
Investigation of the role of Treponema denticola motility and uncharacterized protein TDE0659 in synergistic biofilm formation with Porphyromonas gingivalis
Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species such as Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia contribute to disease progression. ...
Host-pathogen interactions of porphyromonas gingivalis
Periodontal health is supported by various host immune defence mechanisms, which act in concert to maintain host-microbe homeostasis. However, breakdown of homeostasis can lead to the development of chronic periodontitis, ...
Investigations into the effects of head and neck radiotherapy and the potential anticariogenicity of casein phosphopeptide-amorphous calcium phosphate and stannous fluoride
Radiotherapy is the primary treatment modality for most head and neck cancers, in particular, nasopharyngeal carcinoma (NPC). The use of advanced radiotherapy techniques such as intensity modulated radiotherapy (IMRT) ...