Purpose: Biomarkers can be used to predict the incidence or outcome of disease. Currently there are no established biomarkers for oral squamous cell carcinoma (OSCC). Identification of these markers and molecular profiles ...

Porphyromonas gingivalis is a non-motile, Gram-negative coccobacillus, oral anaerobe that is implicated in chronic periodontitis, a polymicrobial inflammatory disease resulting in the destruction of the supporting tissues ...

Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species such as Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia contribute to disease progression. ...

Periodontal health is supported by various host immune defence mechanisms, which act in concert to maintain host-microbe homeostasis. However, breakdown of homeostasis can lead to the development of chronic periodontitis, ...

Radiotherapy is the primary treatment modality for most head and neck cancers, in particular, nasopharyngeal carcinoma (NPC). The use of advanced radiotherapy techniques such as intensity modulated radiotherapy (IMRT) ...

Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT), along with the associated immunosuppression required post transplant, is associated with several potentially debilitating long-term complications, one of ...

Casein phosphopeptide (CPP) complexes have been shown to promote remineralisation of dental tissues affected by dental caries. However, remineralisation takes time and can be limited by the delivery and composition of the ...

This project characterises and assesses the immunological effects of outer membrane vesicles (OMVs) produced by major periodontal pathogens Porphromonas gingivalis, Treponema denticola and Tannerella forsythia. An OMV ...

Demarcated hypomineralised lesions (DHL) of dental enamel are qualitative developmental defects including molar-incisor hypomineralisation (MIH), hypomineralised second primary molars (HSPM) as well as other demarcated ...

Candida albicans has been widely reported in the aetiology of oral cancer. However, the role of its interaction with members of the oral microbiome, such as Actinomyces naeslundii and Streptococcus mutans, in promoting ...