Melbourne Dental School - Theses
Now showing items 1-10 of 70
Characterization of specific inhibitors of Porphyromonas gingivalis gingipains based on their cognate propeptides
Porphyromonas gingivalis is a pathogenic bacterium that has a significant role in the progression of chronic periodontal disease. The cell-surface proteases RgpA, RgpB and Kgp collectively known as the gingipains, are major ...
Quantification of mandibular morphological changes in 3D
Accurate quantification of mandibular morphological changes is important for orthodontic treatment planning and forensic applications. Traditional two-dimensional (2D) cephalometrics are limited to linear distances or ...
Building capacity to promote oral health in an Australian community mental health setting
Half of all Australians will experience a common mental illness during their lifetime. There is strong evidence that people living with mental illness, particularly those living with severe mental illness, experience poor ...
The effect of Treponema denticola on Porphyromonas gingivalis phenotypes and transcriptome
Chronic periodontitis is an inflammatory, bacterial biofilm-associated disease resulting in destruction of the tooth’s supporting tissues. The imminent progression of chronic periodontitis can be predicted by the levels ...
Oral cancer prediction using microRNA in oral swirls
Purpose: To study a clinically convenient sample type, oral swirls as a source of microRNA for analysis in oral disease states. Objectives: To study a panel of OSCC-associated microRNA, identified in next generation ...
Early childhood caries in Cambodia
Children in Cambodia have a severe burden of caries and data from the Cambodian national oral health survey reflect that four in five 6-year-old children have one or more pulpally involved teeth. One of the key features ...
The rectangular block implant: a novel implant design for the posterior atrophic ridge.
A horizontally oriented rectangular block implant (RBI) is proposed: - maximizing the use of the resorbed posterior ridge length and qualifying as a “short” implant, with a surface area equivalent to that of longer cylindrical ...
Implications for an ‘amalgamless’ profession: an Australian perspective
The Minamata Convention on Mercury has committed to a reduction and ultimate elimination in the production and use of mercury containing products. Any consequent 'phase-down' of dental amalgam will change the practice of ...
An assessment for unique biomarker profiles in oral squamous cell carcinoma
Purpose: Biomarkers can be used to predict the incidence or outcome of disease. Currently there are no established biomarkers for oral squamous cell carcinoma (OSCC). Identification of these markers and molecular profiles ...
Characterization of the Porphyromonas gingivalis protein PG1881 and its roles in outer membrane vesicle biogenesis and biofilm formation
Porphyromonas gingivalis is a non-motile, Gram-negative coccobacillus, oral anaerobe that is implicated in chronic periodontitis, a polymicrobial inflammatory disease resulting in the destruction of the supporting tissues ...