HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
Web of Science
AuthorFidler, S; Lewin, S; Deeks, S; Sogaard, OS; Vandekerckhove, L; Collins, S; Kelly, D; Singh, J; Caskey, M; Frater, J
Source TitleJournal of virus eradication
University of Melbourne Author/sLewin, Sharon
Document TypeJournal Article
CitationsFidler, S., Lewin, S., Deeks, S., Sogaard, O. S., Vandekerckhove, L., Collins, S., Kelly, D., Singh, J., Caskey, M. & Frater, J. (2021). HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper. JOURNAL OF VIRUS ERADICATION, 7 (1), https://doi.org/10.1016/j.jve.2020.100025.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719279
This discussion paper addresses the safety of HIV cure studies, particularly those involving stopping antiretroviral therapy, known as an analytic treatment interruption (ATI) in the context of the SARS-CoV-2 pandemic. More than 30 studies listed on ClinicalTrials.gov include an ATI and many others were planned to begin over the next 12 months but most were halted due to the COVID-19 pandemic. We consider the ethics, risks and practical considerations to be taken into account before re-opening HIV cure clinical trials, noting the specific risks of ATI in the context of circulating SARS-CoV-2.
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