Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
AuthorKoutsakos, M; Rowntree, LC; Hensen, L; Chua, BY; van de Sandt, CE; Habel, JR; Zhang, W; Jia, X; Kedzierski, L; Ashhurst, TM; ...
Source TitleCELL REPORTS MEDICINE
University of Melbourne Author/sRowntree, Louise; Kent, Stephen; Lewin, Sharon; Kedzierska, Katherine; Godfrey, Dale; Chung, Amy; Kedzierski, Lukasz; Wheatley, Adam; Audsley, Jennifer; Juno, Jennifer; ...
AffiliationMicrobiology and Immunology
Veterinary and Agricultural Sciences
Document TypeJournal Article
CitationsKoutsakos, M., Rowntree, L. C., Hensen, L., Chua, B. Y., van de Sandt, C. E., Habel, J. R., Zhang, W., Jia, X., Kedzierski, L., Ashhurst, T. M., Putri, G. H., Marsh-Wakefield, F., Read, M. N., Edwards, D. N., Clemens, E. B., Wong, C. Y., Mordant, F. L., Juno, J. A., Amanat, F. ,... Kedzierska, K. (2021). Integrated immune dynamics define correlates of COVID-19 severity and antibody responses. CELL REPORTS MEDICINE, 2 (3), https://doi.org/10.1016/j.xcrm.2021.100208.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862905
NHMRC Grant codeNHMRC/1071916
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18, and IL-10 and broad activation marked by the upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlate with and predict antibody levels and their avidity at convalescence as well as acute neutralization activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, and IL-18, and hyperactivation of innate, adaptive, and myeloid compartments than patients with moderate disease. Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies.
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