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dc.contributor.authorKoutsakos, M
dc.contributor.authorRowntree, LC
dc.contributor.authorHensen, L
dc.contributor.authorChua, BY
dc.contributor.authorvan de Sandt, CE
dc.contributor.authorHabel, JR
dc.contributor.authorZhang, W
dc.contributor.authorJia, X
dc.contributor.authorKedzierski, L
dc.contributor.authorAshhurst, TM
dc.contributor.authorPutri, GH
dc.contributor.authorMarsh-Wakefield, F
dc.contributor.authorRead, MN
dc.contributor.authorEdwards, DN
dc.contributor.authorClemens, EB
dc.contributor.authorWong, CY
dc.contributor.authorMordant, FL
dc.contributor.authorJuno, JA
dc.contributor.authorAmanat, F
dc.contributor.authorAudsley, J
dc.contributor.authorHolmes, NE
dc.contributor.authorGordon, CL
dc.contributor.authorSmibert, OC
dc.contributor.authorTrubiano, JA
dc.contributor.authorHughes, CM
dc.contributor.authorCatton, M
dc.contributor.authorDenholm, JT
dc.contributor.authorTong, SYC
dc.contributor.authorDoolan, DL
dc.contributor.authorKotsimbos, TC
dc.contributor.authorJackson, DC
dc.contributor.authorKrammer, F
dc.contributor.authorGodfrey, D
dc.contributor.authorChung, AW
dc.contributor.authorKing, NJC
dc.contributor.authorLewin, SR
dc.contributor.authorWheatley, AK
dc.contributor.authorKent, SJ
dc.contributor.authorSubbarao, K
dc.contributor.authorMcMahon, J
dc.contributor.authorThevarajan, I
dc.contributor.authorThi, HON
dc.contributor.authorCheng, AC
dc.contributor.authorKedzierska, K
dc.date.accessioned2021-05-04T00:10:24Z
dc.date.available2021-05-04T00:10:24Z
dc.date.issued2021-03-16
dc.identifierpii: S2666-3791(21)00019-7
dc.identifier.citationKoutsakos, M., Rowntree, L. C., Hensen, L., Chua, B. Y., van de Sandt, C. E., Habel, J. R., Zhang, W., Jia, X., Kedzierski, L., Ashhurst, T. M., Putri, G. H., Marsh-Wakefield, F., Read, M. N., Edwards, D. N., Clemens, E. B., Wong, C. Y., Mordant, F. L., Juno, J. A., Amanat, F. ,... Kedzierska, K. (2021). Integrated immune dynamics define correlates of COVID-19 severity and antibody responses. CELL REPORTS MEDICINE, 2 (3), https://doi.org/10.1016/j.xcrm.2021.100208.
dc.identifier.issn2666-3791
dc.identifier.urihttp://hdl.handle.net/11343/272883
dc.description.abstractSARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18, and IL-10 and broad activation marked by the upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlate with and predict antibody levels and their avidity at convalescence as well as acute neutralization activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, and IL-18, and hyperactivation of innate, adaptive, and myeloid compartments than patients with moderate disease. Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies.
dc.languageEnglish
dc.publisherELSEVIER
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleIntegrated immune dynamics define correlates of COVID-19 severity and antibody responses
dc.typeJournal Article
dc.identifier.doi10.1016/j.xcrm.2021.100208
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentDoherty Institute
melbourne.affiliation.departmentVeterinary and Agricultural Sciences
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyVeterinary and Agricultural Sciences
melbourne.source.titleCELL REPORTS MEDICINE
melbourne.source.volume2
melbourne.source.issue3
melbourne.source.pages100208-
melbourne.identifier.nhmrc1071916
melbourne.identifier.nhmrc1113293
melbourne.identifier.nhmrc1117766
melbourne.identifier.nhmrc1123673
melbourne.identifier.nhmrc1136322
melbourne.identifier.nhmrc1135851
melbourne.identifier.nhmrc1145033
melbourne.identifier.nhmrc1162760
melbourne.identifier.nhmrc1149990
melbourne.identifier.nhmrc1132975
melbourne.identifier.nhmrc1091516
melbourne.identifier.nhmrc1177174
melbourne.identifier.nhmrc1173871
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1494046
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862905
melbourne.contributor.authorRowntree, Louise
melbourne.contributor.authorKent, Stephen
melbourne.contributor.authorLewin, Sharon
melbourne.contributor.authorKedzierska, Katherine
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorChung, Amy
melbourne.contributor.authorKedzierski, Lukasz
melbourne.contributor.authorWheatley, Adam
melbourne.contributor.authorAudsley, Jennifer
melbourne.contributor.authorJuno, Jennifer
melbourne.contributor.authorVan de Sandt, Carolien
melbourne.contributor.authorGordon, Claire
melbourne.contributor.authorHensen, Luca
melbourne.contributor.authorChua, Brendon
melbourne.contributor.authorWong, Chinn Yi
melbourne.contributor.authorJackson, David
melbourne.contributor.authorClemens, Ella
melbourne.contributor.authorKoutsakos, Marios
melbourne.contributor.authorMordant, Francesca
melbourne.contributor.authorJia, Xiaoxiao
melbourne.contributor.authorHensen, Luca
melbourne.contributor.authorNguyen, Thi Hoang Oanh
dc.identifier.eissn2666-3791
melbourne.identifier.fundernameidNHMRC, 1071916
melbourne.identifier.fundernameidNHMRC, 1113293
melbourne.identifier.fundernameidNHMRC, 1117766
melbourne.identifier.fundernameidNHMRC, 1123673
melbourne.identifier.fundernameidNHMRC, 1136322
melbourne.identifier.fundernameidNHMRC, 1135851
melbourne.identifier.fundernameidNHMRC, 1145033
melbourne.identifier.fundernameidNHMRC, 1162760
melbourne.identifier.fundernameidNHMRC, 1149990
melbourne.identifier.fundernameidNHMRC, 1132975
melbourne.identifier.fundernameidNHMRC, 1091516
melbourne.identifier.fundernameidNHMRC, 1177174
melbourne.identifier.fundernameidNHMRC, 1173871
melbourne.accessrightsOpen Access


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