Sir Peter MacCallum Department of Oncology
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Immune markers to predict response to neoadjuvant chemoradiotherapy and identifying methods to incorporate immunotherapy in locally advanced rectal cancer (2018)The standard of care for locally advanced rectal cancer (T3-4 +/- N+) is neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME). However, this has been challenged recently with increasing interest ...
(2018)Cancer progression is invariably associated with changes in the stromal microenvironment, most notably, the extracellular matrix (ECM) composition. Laminins (LM) are a family of large trimeric ECM proteins comprised of at ...
The evolutionary history of genes and transcriptional networks reveals fundamental properties of cancer associated with the breakdown of multicellularity (2018)All biological systems follow the rules and constraints imposed during their evolution. Current-day gene phenotypes such as gene expression, gene essentiality, gene function and protein localization are linked with the ...