Sir Peter MacCallum Department of Oncology
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(NATURE RESEARCH, 2021-06-07)Barrett's esophagus in gastrointestinal reflux patients constitutes a columnar epithelium with distal characteristics, prone to progress to esophageal adenocarcinoma. HOX genes are known mediators of position-dependent ...
Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis (ELIFE SCIENCES PUBLICATIONS LTD, 2021-05-18)The formation of new blood vessel networks occurs via angiogenesis during development, tissue repair, and disease. Angiogenesis is regulated by intracellular endothelial signalling pathways, induced downstream of vascular ...
A phase 2 study of momelotinib, a potent JAK1 and JAK2 inhibitor, in patients with polycythemia vera or essential thrombocythemia. (Elsevier BV, 2017-09)Momelotinib is a potent inhibitor of JAK1 and JAK2 that demonstrated efficacy in patients with primary and secondary myelofibrosis. This phase 2, open-label, randomized study evaluated the efficacy and safety of oral ...