Sir Peter MacCallum Department of Oncology
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A Genome-wide RNAi screen identifies combinatorial efficacy of CX-5461 with homologous recombination deficiency and Topoisomerase I inhibition in ovarian cancer (2019)High-grade serous ovarian cancer (HGSC) is common, with poor prognosis. Limited therapeutic options are available, and the development of new therapies is of high priority. The RNA Polymerase I (Pol I) transcription inhibitor ...
Investigating epigenetic perturbations associated with DNMT3A and BCOR mutations in normal and malignant haematopoiesis (2019)Despite recent advances in cancer detection, molecular classification and treatment modalities, the 5-year survival rate of acute myeloid leukaemia (AML) has not changed in 30 years. The unique genetic context created by ...
Immune markers to predict response to neoadjuvant chemoradiotherapy and identifying methods to incorporate immunotherapy in locally advanced rectal cancer (2018)The standard of care for locally advanced rectal cancer (T3-4 +/- N+) is neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME). However, this has been challenged recently with increasing interest ...