Effect of chronic electrical stimulation on cochlear nucleus neuron size in normal hearing kittens
AuthorNi, Daofeng; Seldon, H. Lee.; Shepherd, Robert K.; Clark, Graeme M.
Source TitleActa Oto-laryngologica
Document TypeJournal Article
CitationsNi, D., Seldon, H. L., Shepherd, R. K., & Clark, G. M. (1993). Effect of chronic electrical stimulation on cochlear nucleus neuron size in normal hearing kittens. Acta Oto-laryngologica, 113, 489-497.
Access StatusThis item is currently not available from this repository
Publisher’s permission requested and denied.
Very young cochlear-implant candidates may have undetected islands of residual hearing. Would the maturation of these functioning auditory neurons be affected by chronic cochlear stimulation? This was tested by examining neuron sizes in the cochlear nuclei of young, normal hearing kittens with and without chronic cochlear stimulation. Six animals received bilateral intra-or extracochlear implants and were electrically stimulated unilaterally for periods of 1,000-1,500 hours. After sacrifice, cross-sectional areas of approximately 11,000 neuron somata in the cochlear nuclei were measured with an image-analysis system. There were statistically significant differences between stimulated and unstimulated nuclei, especially the posteroventral cochlear nucleus (PYCN), in individual cats, but the directions of the differences were inconsistent. Overall, there was no significant effect of electrical stimulation on soma size. These results indicate that chronic electrical stimulation of the auditory nerve has no positive or negative trophic effects on otherwise innervated, maturing cochlear nucleus neurons.
Keywordscochlear implant; safety studies; residual hearing
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References
- Graeme Clark Collection