Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents
AuthorEurtivong, C; Pilkington, LI; van Rensburg, M; White, RM; Brar, HK; Rees, S; Paulin, EK; Xu, CS; Sharma, N; Leung, IKH; ...
Source TitleEuropean Journal of Medicinal Chemistry
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
University of Melbourne Author/sLeung, Ivanhoe
AffiliationSchool of Chemistry
Document TypeJournal Article
CitationsEurtivong, C., Pilkington, L. I., van Rensburg, M., White, R. M., Brar, H. K., Rees, S., Paulin, E. K., Xu, C. S., Sharma, N., Leung, I. K. H., Leung, E., Barker, D. & Reynisson, J. (2020). Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 187, https://doi.org/10.1016/j.ejmech.2019.111919.
Access StatusAccess this item via the Open Access location
Open Access URLhttps://eprints.keele.ac.uk/7517/1/PC-PLC-EurJMedChem.docx
Phosphatidylcholine-specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits from four different structural series that contain the molecular scaffold of benzenesulphonamides (10), pyrido[3,4-b]indoles (22), morpholinobenzoic acid (84) and benzamidobenzoic acid (80). 164 structural analogues were tested to investigate the chemical space around the hit series and to generate preliminary structurally activity relationships (SAR). Two of the pyrido[3,4-b]indoles (22_10 and 22_15) had comparable or better potency as D609, an established but non-drug-like PC-PLC inhibitor. Furthermore, three morpholinobenzoic acids (84, 84_4 and 84_5) had superior potency than D609. Therefore, this study paves the way towards the development of drug-like PL-PLC inhibitors as potential anticancer agents.
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