Show simple item record

dc.contributor.authorShepherd, R. K.en_US
dc.contributor.authorXu, S. A.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.date.accessioned2014-05-21T20:21:57Z
dc.date.available2014-05-21T20:21:57Z
dc.date.issued1994en_US
dc.identifier.citationShepherd, R. K., Xu, S. A., & Clark, G. M. (1994). Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid. Hearing Research, 72, 89-98.en_US
dc.identifier.urihttp://hdl.handle.net/11343/27381
dc.descriptionPublisher’s permission requested and denied.en_US
dc.description.abstractCo-administration of kanamycin (KA) with the loop diuretic ethacrynic acid (EA) rapidly produces a profound hearing loss in the cat while maintaining normal renal function [Xu et al., Hear. Res. 70, 205-215 (1993)]. In the present paper we have applied this deafening procedure to the old world monkey Macaca fascicularis (macaque). Following the co-administration of KA and EA, the hearing loss in the macaque developed far slower than we observed in the cat. Moreover, unlike the cat, there was evidence of a partial recovery in the animal’s hearing, resulting in a bilaterally symmetrical high frequency hearing loss. The extent of this hearing loss was dependent on the dose of the EA administered. Finally, the most unexpected result of the present study was the degree of acute nephrotoxicity experienced by these animals following the drug administration. The sensitivity of this species to renal failure restricted the dose of EA that could be safely administered. In conclusion, the co-administration of KA and EA cannot reliably produce a profound hearing loss in the macaque. While it can produce a dose dependent high frequency hearing loss the animal will also experience acute renal failure that requires careful management.en_US
dc.relation.ispartofScientific publications, vol.8, 1994-1995, no.515en_US
dc.relation.isversionofhttp://tinyurl.com/3rxtddsen_US
dc.subjectototoxicityen_US
dc.subjectnephrotoxicityen_US
dc.subjecthearing lossen_US
dc.subjectaminoglycosidesen_US
dc.subjectloop diureticsen_US
dc.subjectdeafnessen_US
dc.subjectcochlear implantsen_US
dc.titlePartial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic aciden_US
dc.typeJournal Articleen_US
melbourne.source.titleHearing Researchen_US
melbourne.source.volume72en_US
melbourne.source.pages89-98en_US
melbourne.elementsidNA
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorShepherd, Robert
melbourne.accessrightsThis item is currently not available from this repository


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record